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1y2q

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(New page: 200px<br /><applet load="1y2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y2q, resolution 1.95&Aring;" /> '''Crystal structure of...)
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[[Image:1y2q.gif|left|200px]]<br /><applet load="1y2q" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1y2q, resolution 1.95&Aring;" />
 
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'''Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi'''<br />
 
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==Overview==
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==Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi==
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We report the crystal structure of an archaea-specific editing domain of, threonyl-tRNA synthetase that reveals a marked structural similarity to, D-amino acid deacylases found in eubacteria and eukaryotes. The domain can, bind D-amino acids despite a low sequence identity to other D-amino acid, deacylases. These results together indicate the presence of these, deacylases in all three kingdoms of life. This underlines an important, role they may have played in enforcing homochirality during translation.
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<StructureSection load='1y2q' size='340' side='right'caption='[[1y2q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2q OCA], [https://pdbe.org/1y2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2q RCSB], [https://www.ebi.ac.uk/pdbsum/1y2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT_PYRAB SYT_PYRAB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2q ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Y2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Active as [http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y2Q OCA].
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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A D-amino acid editing module coupled to the translational apparatus in archaea., Dwivedi S, Kruparani SP, Sankaranarayanan R, Nat Struct Mol Biol. 2005 Jun;12(6):556-7. Epub 2005 May 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15908961 15908961]
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[[Category: Large Structures]]
[[Category: Pyrococcus abyssi]]
[[Category: Pyrococcus abyssi]]
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[[Category: Single protein]]
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[[Category: Dwivedi S]]
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[[Category: Threonine--tRNA ligase]]
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[[Category: Kruparani SP]]
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[[Category: Dwivedi, S.]]
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[[Category: Sankaranarayanan R]]
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[[Category: Kruparani, S.P.]]
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[[Category: Sankaranarayanan, R.]]
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[[Category: beta-alpha-beta fold]]
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[[Category: editing domain]]
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[[Category: trna-synthetase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:31:21 2007''
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Current revision

Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi

PDB ID 1y2q

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