1gp7

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{{Seed}}
 
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[[Image:1gp7.png|left|200px]]
 
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==Acidic Phospholipase A2 from venom of Ophiophagus Hannah==
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The line below this paragraph, containing "STRUCTURE_1gp7", creates the "Structure Box" on the page.
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<StructureSection load='1gp7' size='340' side='right'caption='[[1gp7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gp7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GP7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1gp7| PDB=1gp7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp7 OCA], [https://pdbe.org/1gp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gp7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gp7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2A1_OPHHA PA2A1_OPHHA] Snake venom phospholipase A2 (PLA2) that may exhibit cardiotoxicity, myotoxicity, antiplatelet activity, and edema-inducing activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:9028866</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/1gp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gp7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
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===ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH===
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Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop".,Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659<ref>PMID:12217659</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gp7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12217659}}, adds the Publication Abstract to the page
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12217659 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12217659}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1GP7 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA].
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==Reference==
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<ref group="xtra">PMID:12217659</ref><references group="xtra"/>
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[[Category: Ophiophagus hannah]]
[[Category: Ophiophagus hannah]]
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[[Category: Lin, Z.]]
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[[Category: Lin Z]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Calcium]]
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[[Category: Cardiotoxic activity]]
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[[Category: Crystal structure]]
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[[Category: Hydrolase]]
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[[Category: King cobra]]
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[[Category: Lipid degradation]]
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[[Category: Myotoxic activity]]
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[[Category: Pancreatic loop]]
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[[Category: Phospholipase a2]]
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[[Category: Snake venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:56:21 2009''
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Current revision

Acidic Phospholipase A2 from venom of Ophiophagus Hannah

PDB ID 1gp7

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