2nn2

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{{Seed}}
 
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[[Image:2nn2.png|left|200px]]
 
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==Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator==
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The line below this paragraph, containing "STRUCTURE_2nn2", creates the "Structure Box" on the page.
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<StructureSection load='2nn2' size='340' side='right'caption='[[2nn2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NN2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn2 OCA], [https://pdbe.org/2nn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2nn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nn2 ProSAT]</span></td></tr>
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{{STRUCTURE_2nn2| PDB=2nn2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/2nn2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nn2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a protein-protein interaction motif that contains a dimerization interface, a possible oligomerization surface, and surfaces for interactions with other factors, including nuclear co-repressors and histone deacetylases. The BTB-ZF protein LRF (also known as ZBTB7, FBI-1, OCZF, and Pokemon) is a master regulator of oncogenesis, and represses the transcription of a variety of important genes, including the ARF, c-fos, and c-myc oncogenes and extracellular matrix genes. We determined the crystal structure of the BTB domain from human LRF to 2.1 A and observed the canonical BTB homodimer fold. However, novel features are apparent on the surface of the homodimer, including differences in the lateral groove and charged pocket regions. The residues that line the lateral groove have little similarity with the equivalent residues from the BCL6 BTB domain, and we show that the 17-residue BCL6 Binding Domain (BBD) from the SMRT co-repressor does not bind to the LRF BTB domain.
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===Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator===
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Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.,Stogios PJ, Chen L, Prive GG Protein Sci. 2007 Feb;16(2):336-42. Epub 2006 Dec 22. PMID:17189472<ref>PMID:17189472</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17189472}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2nn2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17189472 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17189472}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2NN2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN2 OCA].
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==Reference==
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<ref group="xtra">PMID:17189472</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Large Structures]]
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[[Category: Prive, G G.]]
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[[Category: Chen L]]
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[[Category: Stogios, P J.]]
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[[Category: Prive GG]]
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[[Category: Btb domain]]
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[[Category: Stogios PJ]]
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[[Category: Candidate oncoprotein]]
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[[Category: Poz domain]]
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[[Category: Protein-protein interaction domain]]
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[[Category: Transcription repressor]]
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[[Category: Zinc-finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:01:25 2009''
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Current revision

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator

PDB ID 2nn2

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