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1hkw

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{{Seed}}
 
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[[Image:1hkw.png|left|200px]]
 
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<!--
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==MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA)==
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The line below this paragraph, containing "STRUCTURE_1hkw", creates the "Structure Box" on the page.
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<StructureSection load='1hkw' size='340' side='right'caption='[[1hkw]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1hkw| PDB=1hkw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkw OCA], [https://pdbe.org/1hkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkw RCSB], [https://www.ebi.ac.uk/pdbsum/1hkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkw ProSAT]</span></td></tr>
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</table>
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===MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LYSA)===
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== Function ==
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[https://www.uniprot.org/uniprot/DCDA_MYCTU DCDA_MYCTU] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host.<ref>PMID:12637582</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12637582}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12637582 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkw_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12637582}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HKW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKW OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkw ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:12637582</ref><references group="xtra"/>
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<references/>
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[[Category: Diaminopimelate decarboxylase]]
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__TOC__
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[[Category: Mycobacterium tuberculosis]]
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</StructureSection>
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[[Category: Gokulan, K.]]
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[[Category: Large Structures]]
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[[Category: Junior, M S.Pavelka.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Junior, W R.Jacobs.]]
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[[Category: Gokulan K]]
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[[Category: Rupp, B.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Sacchettini, J C.]]
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[[Category: Pavelka Jr MS]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Rupp B]]
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[[Category: Dapdc]]
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[[Category: Sacchettini JC]]
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[[Category: Decarboxylase]]
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[[Category: Diaminopimelate]]
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[[Category: Lyase]]
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[[Category: Lysine pathway]]
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[[Category: Lysine synthetic pathway]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Plp]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Tb]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:20:47 2009''
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Current revision

MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA)

PDB ID 1hkw

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