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| | {{Structure | | {{Structure |
| - | |PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[2rh1]], resolution 2.40Å (<scene name='initialview01'>default scene</scene>)}}} | + | |PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[2rh1]], [[Resolution|resolution]] 2.40Å (<scene name='initialview01'>default scene</scene>)}}} |
| - | |SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+12p+A+416'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+Acm+A+411'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Bu1+A+409'>AC3</scene>, <scene name='pdbsite=AC5:Binding+Site+For+Residue+Cau+A+408'>AC5</scene>, <scene name='pdbsite=AC6:Binding+Site+For+Residue+Clr+A+412'>AC6</scene>, <scene name='pdbsite=AC7:Binding+Site+For+Residue+Clr+A+413'>AC7</scene>, <scene name='pdbsite=AC9:Binding+Site+For+Residue+Mal+A+401'>AC9</scene>, <scene name='pdbsite=BC1:Binding+Site+For+Residue+Plm+A+415'>BC1</scene>, <scene name='pdbsite=BC2:Binding+Site+For+Residue+So4+A+402'>BC2</scene>, <scene name='pdbsite=BC3:Binding+Site+For+Residue+So4+A+403'>BC3</scene>, <scene name='pdbsite=BC4:Binding+Site+For+Residue+So4+A+404'>BC4</scene>, <scene name='pdbsite=BC5:Binding+Site+For+Residue+So4+A+405'>BC5</scene>, <scene name='pdbsite=BC6:Binding+Site+For+Residue+So4+A+406'>BC6</scene> and <scene name='pdbsite=BC7:Binding+Site+For+Residue+So4+A+407'>BC7</scene>
| + | |LIGAND= <scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |LIGAND= <scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MAL:SUGAR+(MALTOSE)'>MAL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | |GENE= ADRB2, ADRB2R, B2AR / E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4]) |
| - | |GENE= ADRB2, ADRB2R, B2AR / E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Homo sapiens, Enterobacteria phage T4]) | + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2rh1 PDBsum]</span> |
| - | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00735 bacteriophage_T4-like_lysozyme], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00001 7tm_1]</span> | + | |SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/domain/2rh1A01 2Rh1A01], [http://www.cathdb.info/domain/2rh1A02 2Rh1A02]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001165 Ipr001165], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002196 Ipr002196], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR023346 Ipr023346], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR017452 Ipr017452], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000276 Ipr000276], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000332 Ipr000332], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002233 Ipr002233], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR023347 Ipr023347]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00001 PF00001], [http://pfam.sanger.ac.uk/family?acc=PF00959 PF00959]</span> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rh1 OCA], [http://www.ebi.ac.uk/pdbsum/2rh1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rh1 RCSB]</span> | + | |uPDB=2RH1|CONSURF={{!}}- |
| - | |FUNCTION={{GO|id=GO:0004930 | text = G-protein coupled receptor activity}}{{GO|id=GO:0042803 | text = protein homodimerization activity}}{{GO|id=GO:0001584 | text = rhodopsin-like receptor activity}}{{GO|id=GO:0051380 | text = norepinephrine binding}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0008144 | text = drug binding}}{{GO|id=GO:0004939 | text = beta-adrenergic receptor activity}}{{GO|id=GO:0004935 | text = adrenoceptor activity}}{{GO|id=GO:0004941 | text = beta2-adrenergic receptor activity}}{{GO|id=GO:0004872 | text = receptor activity}}{{GO|id=GO:0004871 | text = signal transducer activity}}{{GO|id=GO:0032403 | text = protein complex binding}}
| + | |
| - | |PROCESS={{GO|id=GO:0002032 | text = desensitization of G-protein coupled receptor protein signaling pathway by arrestin}}{{GO|id=GO:0030501 | text = positive regulation of bone mineralization}}{{GO|id=GO:0030279 | text = negative regulation of ossification}}{{GO|id=GO:0008284 | text = positive regulation of cell proliferation}}{{GO|id=GO:0007189 | text = G-protein signaling, adenylate cyclase activating pathway}}{{GO|id=GO:0007171 | text = activation of transmembrane receptor protein tyrosine kinase activity}}{{GO|id=GO:0002024 | text = diet induced thermogenesis}}{{GO|id=GO:0000187 | text = activation of MAPK activity}}{{GO|id=GO:0002028 | text = regulation of sodium ion transport}}{{GO|id=GO:0050873 | text = brown fat cell differentiation}}{{GO|id=GO:0043065 | text = positive regulation of apoptosis}}{{GO|id=GO:0040015 | text = negative regulation of multicellular organism growth}}{{GO|id=GO:0007188 | text = G-protein signaling, coupled to cAMP nucleotide second messenger}}{{GO|id=GO:0045986 | text = negative regulation of smooth muscle contraction}}{{GO|id=GO:0002025 | text = vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure}}{{GO|id=GO:0048633 | text = positive regulation of skeletal muscle growth}}{{GO|id=GO:0007190 | text = activation of adenylate cyclase activity}}{{GO|id=GO:0007165 | text = signal transduction}}{{GO|id=GO:0045453 | text = bone resorption}}{{GO|id=GO:0007243 | text = protein kinase cascade}}{{GO|id=GO:0007186 | text = G-protein coupled receptor protein signaling pathway}}{{GO|id=GO:0007166 | text = cell surface receptor linked signal transduction}}{{GO|id=GO:0051927 | text = negative regulation of calcium ion transport via voltage-gated calcium channel}}{{GO|id=GO:0043410 | text = positive regulation of MAPKKK cascade}}{{GO|id=GO:0009409 | text = response to cold}}{{GO|id=GO:0006898 | text = receptor-mediated endocytosis}}{{GO|id=GO:0051930 | text = regulation of sensory perception of pain}}{{GO|id=GO:0045909 | text = positive regulation of vasodilation}}{{GO|id=GO:0045823 | text = positive regulation of heart contraction}}{{GO|id=GO:0050728 | text = negative regulation of inflammatory response}}{{GO|id=GO:0045944 | text = positive regulation of transcription from RNA polymerase II promoter}}{{GO|id=GO:0031649 | text = heat generation}}{{GO|id=GO:0008333 | text = endosome to lysosome transport}}
| + | |
| - | |COMPONENT={{GO|id=GO:0005624 | text = membrane fraction}}{{GO|id=GO:0030425 | text = dendrite}}{{GO|id=GO:0016021 | text = integral to membrane}}{{GO|id=GO:0005634 | text = nucleus}}{{GO|id=GO:0030424 | text = axon}}{{GO|id=GO:0044424 | text = intracellular part}}{{GO|id=GO:0005886 | text = plasma membrane}}{{GO|id=GO:0005764 | text = lysosome}}{{GO|id=GO:0016324 | text = apical plasma membrane}}{{GO|id=GO:0016020 | text = membrane}}{{GO|id=GO:0005768 | text = endosome}}{{GO|id=GO:0043235 | text = receptor complex}}{{GO|id=GO:0042383 | text = sarcolemma}}{{GO|id=GO:0005887 | text = integral to plasma membrane}}
| + | |
| - | |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000276 Ipr000276], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000332 Ipr000332], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002233 Ipr002233], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR017452 Ipr017452]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00001 PF00001]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P07550 P07550]</span>
| + | |
| - | |CONSURF={{!}}- | + | |
| | {{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]] | | {{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]] |
| | {{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" | | {{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" |
