1ze3

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{{Seed}}
 
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[[Image:1ze3.png|left|200px]]
 
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==Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH==
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The line below this paragraph, containing "STRUCTURE_1ze3", creates the "Structure Box" on the page.
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<StructureSection load='1ze3' size='340' side='right'caption='[[1ze3]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ze3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZE3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_1ze3| PDB=1ze3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ze3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ze3 OCA], [https://pdbe.org/1ze3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ze3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ze3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ze3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIMC_ECOLI FIMC_ECOLI] Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/1ze3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ze3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adhesive type 1 pili from uropathogenic Escherichia coli are filamentous protein complexes that are attached to the assembly platform FimD in the outer membrane. During pilus assembly, FimD binds complexes between the chaperone FimC and type 1 pilus subunits in the periplasm and mediates subunit translocation to the cell surface. Here we report nuclear magnetic resonance and X-ray protein structures of the N-terminal substrate recognition domain of FimD (FimD(N)) before and after binding of a chaperone-subunit complex. FimD(N) consists of a flexible N-terminal segment of 24 residues, a structured core with a novel fold, and a C-terminal hinge segment. In the ternary complex, residues 1-24 of FimD(N) specifically interact with both FimC and the subunit, acting as a sensor for loaded FimC molecules. Together with in vivo complementation studies, we show how this mechanism enables recognition and discrimination of different chaperone-subunit complexes by bacterial pilus assembly platforms.
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===Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH===
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Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD.,Nishiyama M, Horst R, Eidam O, Herrmann T, Ignatov O, Vetsch M, Bettendorff P, Jelesarov I, Grutter MG, Wuthrich K, Glockshuber R, Capitani G EMBO J. 2005 Jun 15;24(12):2075-86. Epub 2005 May 26. PMID:15920478<ref>PMID:15920478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ze3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15920478}}, adds the Publication Abstract to the page
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15920478 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15920478}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZE3 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE3 OCA].
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==Reference==
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<ref group="xtra">PMID:15920478</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bettendorff, P.]]
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[[Category: Large Structures]]
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[[Category: Capitani, G.]]
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[[Category: Bettendorff P]]
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[[Category: Eidam, O.]]
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[[Category: Capitani G]]
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[[Category: Glockshuber, R.]]
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[[Category: Eidam O]]
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[[Category: Grutter, M G.]]
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[[Category: Glockshuber R]]
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[[Category: Herrmann, T.]]
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[[Category: Grutter MG]]
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[[Category: Horst, R.]]
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[[Category: Herrmann T]]
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[[Category: Ignatov, O.]]
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[[Category: Horst R]]
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[[Category: Jelesarov, I.]]
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[[Category: Ignatov O]]
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[[Category: Nishiyama, M.]]
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[[Category: Jelesarov I]]
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[[Category: Vetsch, M.]]
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[[Category: Nishiyama M]]
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[[Category: Wuthrich, K.]]
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[[Category: Vetsch M]]
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[[Category: Soluble domain]]
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[[Category: Wuthrich K]]
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[[Category: Ternary complex with chaperone and pilus subunit]]
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[[Category: Usher]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:29:43 2009''
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Current revision

Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH

PDB ID 1ze3

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