1z98

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:43, 21 November 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1z98.png|left|200px]]
 
-
<!--
+
==Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation==
-
The line below this paragraph, containing "STRUCTURE_1z98", creates the "Structure Box" on the page.
+
<StructureSection load='1z98' size='340' side='right'caption='[[1z98]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1z98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z98 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-
{{STRUCTURE_1z98| PDB=1z98 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z98 OCA], [https://pdbe.org/1z98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z98 RCSB], [https://www.ebi.ac.uk/pdbsum/1z98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z98 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q41372_SPIOL Q41372_SPIOL]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z98_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z98 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane. Channel closure results either from the dephosphorylation of two conserved serine residues under conditions of drought stress, or from the protonation of a conserved histidine residue following a drop in cytoplasmic pH due to anoxia during flooding. Here we report the X-ray structure of the spinach plasma membrane aquaporin SoPIP2;1 in its closed conformation at 2.1 A resolution and in its open conformation at 3.9 A resolution, and molecular dynamics simulations of the initial events governing gating. In the closed conformation loop D caps the channel from the cytoplasm and thereby occludes the pore. In the open conformation loop D is displaced up to 16 A and this movement opens a hydrophobic gate blocking the channel entrance from the cytoplasm. These results reveal a molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins.
-
===Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation===
+
Structural mechanism of plant aquaporin gating.,Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M, Tajkhorshid E, Neutze R, Kjellbom P Nature. 2006 Feb 9;439(7077):688-94. Epub 2005 Dec 7. PMID:16340961<ref>PMID:16340961</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1z98" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16340961}}, adds the Publication Abstract to the page
+
*[[Aquaporin 3D structures|Aquaporin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16340961 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16340961}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1Z98 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z98 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16340961</ref><references group="xtra"/>
+
[[Category: Spinacia oleracea]]
[[Category: Spinacia oleracea]]
-
[[Category: Hedfalk, K.]]
+
[[Category: Hedfalk K]]
-
[[Category: Johanson, U.]]
+
[[Category: Johanson U]]
-
[[Category: Karlsson, M.]]
+
[[Category: Karlsson M]]
-
[[Category: Kjellbom, P.]]
+
[[Category: Kjellbom P]]
-
[[Category: Neutze, R.]]
+
[[Category: Neutze R]]
-
[[Category: Tornroth-Horsefield, S.]]
+
[[Category: Tornroth-Horsefield S]]
-
[[Category: Alpha-helical]]
+
-
[[Category: Aquaporin]]
+
-
[[Category: Integral membrane protein]]
+
-
[[Category: Pip]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:37:19 2009''
+

Current revision

Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation

PDB ID 1z98

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z98"
Personal tools