1yov

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{{Seed}}
 
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[[Image:1yov.png|left|200px]]
 
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==Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8==
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The line below this paragraph, containing "STRUCTURE_1yov", creates the "Structure Box" on the page.
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<StructureSection load='1yov' size='340' side='right'caption='[[1yov]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ngv 1ngv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YOV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1yov| PDB=1yov | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yov OCA], [https://pdbe.org/1yov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yov RCSB], [https://www.ebi.ac.uk/pdbsum/1yov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yov ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBA3_HUMAN UBA3_HUMAN] Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.<ref>PMID:10207026</ref> <ref>PMID:9694792</ref> <ref>PMID:12740388</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yo/1yov_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yov ConSurf].
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<div style="clear:both"></div>
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===Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8===
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==See Also==
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*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12646924 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12646924}}
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==About this Structure==
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1YOV is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ngv 1ngv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOV OCA].
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==Reference==
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<ref group="xtra">PMID:12646924</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Podgorski, M S.]]
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[[Category: Large Structures]]
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[[Category: Schulman, B A.]]
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[[Category: Podgorski MS]]
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[[Category: Walden, H.]]
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[[Category: Schulman BA]]
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[[Category: Appbp1]]
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[[Category: Walden H]]
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[[Category: E1]]
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[[Category: Nedd8]]
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[[Category: Uba3]]
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[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:49:23 2009''
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Current revision

Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8

PDB ID 1yov

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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