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2p2k

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{{Seed}}
 
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[[Image:2p2k.png|left|200px]]
 
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<!--
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==Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe==
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The line below this paragraph, containing "STRUCTURE_2p2k", creates the "Structure Box" on the page.
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<StructureSection load='2p2k' size='340' side='right'caption='[[2p2k]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p2k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P2K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_2p2k| PDB=2p2k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p2k OCA], [https://pdbe.org/2p2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p2k RCSB], [https://www.ebi.ac.uk/pdbsum/2p2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p2k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/2p2k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p2k ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe===
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==See Also==
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*[[Concanavalin 3D structures|Concanavalin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17881248 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_17881248}}
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==About this Structure==
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2P2K is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2K OCA].
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==Reference==
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<ref group="xtra">PMID:17881248</ref><references group="xtra"/>
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[[Category: Canavalia gladiata]]
[[Category: Canavalia gladiata]]
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[[Category: Benevides, G B.]]
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[[Category: Large Structures]]
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[[Category: Bezerra, G A.]]
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[[Category: Benevides GB]]
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[[Category: Cavada, B S.]]
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[[Category: Bezerra GA]]
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[[Category: Delatorre, P.]]
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[[Category: Cavada BS]]
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[[Category: Jr., W F.de Azevedo.]]
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[[Category: Delatorre P]]
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[[Category: Moreno, F B.M B.]]
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[[Category: Moreno FBMB]]
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[[Category: Oliveira, T M.]]
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[[Category: Oliveira TM]]
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[[Category: Rocha, B A.M.]]
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[[Category: Rocha BAM]]
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[[Category: Souza, E P.]]
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[[Category: Souza EP]]
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[[Category: Canavalia gladiata lectin]]
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[[Category: De Azevedo Jr WF]]
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[[Category: Dimannoside]]
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[[Category: Man1-4man-ome]]
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[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:53:33 2009''
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Current revision

Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe

PDB ID 2p2k

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