1sse

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{{Seed}}
 
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[[Image:1sse.png|left|200px]]
 
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==Solution structure of the oxidized form of the Yap1 redox domain==
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The line below this paragraph, containing "STRUCTURE_1sse", creates the "Structure Box" on the page.
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<StructureSection load='1sse' size='340' side='right'caption='[[1sse]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sse]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sse OCA], [https://pdbe.org/1sse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sse RCSB], [https://www.ebi.ac.uk/pdbsum/1sse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sse ProSAT]</span></td></tr>
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{{STRUCTURE_1sse| PDB=1sse | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the oxidized form of the Yap1 redox domain===
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[https://www.uniprot.org/uniprot/AP1_YEAST AP1_YEAST] Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX2), and thiol-specific peroxidases (TSA1, AHP1). The induction of some of these genes requires the cooperative action of both, YAP1 and SKN7. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress (as well as carbon stress, but not increased temperature, acidic pH, or ionic stress) induces nuclear accumulation and as a result YAP1 transcriptional activity. Activation by hydrogen peroxide or thiol-reactive chemicals elicit distinct adaptive gene responses. Nuclear export is restored when disulfide bonds are reduced by thioredoxin (TRX2), whose expression is controlled by YAP1, providing a mechanism for negative autoregulation. When overexpressed, YAP1 confers pleiotropic drug-resistance and increases cellular tolerance to cadmium, iron chelators and zinc.<ref>PMID:10347154</ref> <ref>PMID:11013218</ref> <ref>PMID:11274141</ref> <ref>PMID:11509657</ref> <ref>PMID:12006656</ref> <ref>PMID:12437921</ref> <ref>PMID:12582119</ref> <ref>PMID:12743123</ref> <ref>PMID:14556629</ref> <ref>PMID:14556853</ref> <ref>PMID:1525853</ref> <ref>PMID:20971184</ref> <ref>PMID:8182076</ref> <ref>PMID:9065458</ref> <ref>PMID:9372930</ref> <ref>PMID:9469820</ref> <ref>PMID:9857197</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15318225}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15318225 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1sse_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15318225}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sse ConSurf].
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1SSE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSE OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:15318225</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Storz, G.]]
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[[Category: Storz G]]
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[[Category: Tjandra, N.]]
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[[Category: Tjandra N]]
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[[Category: Wood, M J.]]
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[[Category: Wood MJ]]
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[[Category: Disulfide bond]]
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[[Category: Ne]]
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[[Category: Nuclear export signal]]
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[[Category: Redox-regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:18:12 2009''
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Current revision

Solution structure of the oxidized form of the Yap1 redox domain

PDB ID 1sse

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