2hl5

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{{Seed}}
 
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[[Image:2hl5.png|left|200px]]
 
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==Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)==
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The line below this paragraph, containing "STRUCTURE_2hl5", creates the "Structure Box" on the page.
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<StructureSection load='2hl5' size='340' side='right'caption='[[2hl5]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hl5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HL5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2hl5| PDB=2hl5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hl5 OCA], [https://pdbe.org/2hl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hl5 RCSB], [https://www.ebi.ac.uk/pdbsum/2hl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hl5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hl5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hl5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)===
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==See Also==
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*[[Dynactin|Dynactin]]
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*[[End-binding protein|End-binding protein]]
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*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 16949363 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_16949363}}
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Neuropathy, distal hereditary motor, type VIIB OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601143 601143]], Amyotrophic lateral sclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601143 601143]]
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==About this Structure==
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2HL5 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HL5 OCA].
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==Reference==
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<ref group="xtra">PMID:16949363</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Honnappa, S.]]
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[[Category: Large Structures]]
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[[Category: Steinmetz, M O.]]
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[[Category: Honnappa S]]
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[[Category: Winkler, F K.]]
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[[Category: Steinmetz MO]]
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[[Category: +tip protein complex structure]]
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[[Category: Winkler FK]]
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[[Category: Coiled coil]]
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[[Category: Cytoskeleton associated protein]]
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[[Category: Dynactin]]
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[[Category: Eb1]]
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[[Category: Microtubule binding]]
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[[Category: P150glued]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:19:04 2009''
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Current revision

Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)

PDB ID 2hl5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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