1si2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:30, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1si2.png|left|200px]]
 
-
<!--
+
==Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang==
-
The line below this paragraph, containing "STRUCTURE_1si2", creates the "Structure Box" on the page.
+
<StructureSection load='1si2' size='340' side='right'caption='[[1si2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1si2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SI2 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1si2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1si2 OCA], [https://pdbe.org/1si2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1si2 RCSB], [https://www.ebi.ac.uk/pdbsum/1si2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1si2 ProSAT]</span></td></tr>
-
{{STRUCTURE_1si2| PDB=1si2 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/si/1si2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1si2 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang===
+
==See Also==
-
 
+
*[[Argonaute 3D structures|Argonaute 3D structures]]
-
 
+
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_15152257}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15152257 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_15152257}}
+
-
 
+
-
==About this Structure==
+
-
1SI2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SI2 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15152257</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ma, J B.]]
+
[[Category: Large Structures]]
-
[[Category: Patel, D.]]
+
[[Category: Ma JB]]
-
[[Category: Ye, K.]]
+
[[Category: Patel D]]
-
[[Category: Double helix]]
+
[[Category: Ye K]]
-
[[Category: Overhang]]
+
-
[[Category: Protein-rna complex]]
+
-
[[Category: Rna interference]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:40:47 2009''
+

Current revision

Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang

PDB ID 1si2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1si2"
Personal tools