1q9g

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[[Image:1q9g.png|left|200px]]
 
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==NMR STRUCTURE OF THE OUTER MEMBRANE PROTEIN OMPX IN DHPC MICELLES==
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The line below this paragraph, containing "STRUCTURE_1q9g", creates the "Structure Box" on the page.
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<StructureSection load='1q9g' size='340' side='right'caption='[[1q9g]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q9G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9g OCA], [https://pdbe.org/1q9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q9g RCSB], [https://www.ebi.ac.uk/pdbsum/1q9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q9g ProSAT]</span></td></tr>
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{{STRUCTURE_1q9g| PDB=1q9g | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OMPX_ECOLI OMPX_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/1q9g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q9g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the integral membrane protein OmpX from Escherichia coli reconstituted in 60 kDa DHPC micelles (OmpX/DHPC) was calculated from 526 NOE upper limit distance constraints. The structure determination was based on complete sequence-specific assignments for the amide protons and the Val, Leu, and Ile(delta1) methyl groups in OmpX, which were selectively protonated on a perdeuterated background. The solution structure of OmpX in the DHPC micelles consists of a well-defined, eight-stranded antiparallel beta-barrel, with successive pairs of beta-strands connected by mobile loops. Several long-range NOEs observed outside of the transmembrane barrel characterize an extension of a four-stranded beta-sheet beyond the height of the barrel. This protruding beta-sheet is believed to be involved in intermolecular interactions responsible for the biological functions of OmpX. The present approach for de novo structure determination should be quite widely applicable to membrane proteins reconstituted in mixed micelles with overall molecular masses up to about 100 kDa, and may also provide a platform for additional functional studies.
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===NMR STRUCTURE OF THE OUTER MEMBRANE PROTEIN OMPX IN DHPC MICELLES===
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NMR structure of the integral membrane protein OmpX.,Fernandez C, Hilty C, Wider G, Guntert P, Wuthrich K J Mol Biol. 2004 Mar 5;336(5):1211-21. PMID:15037080<ref>PMID:15037080</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1q9g" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15037080 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15037080}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Q9G is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9G OCA].
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==Reference==
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<ref group="xtra">PMID:15037080</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Fernandez, C.]]
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[[Category: Large Structures]]
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[[Category: Guntert, P.]]
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[[Category: Fernandez C]]
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[[Category: Hilty, C.]]
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[[Category: Guntert P]]
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[[Category: Wider, G.]]
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[[Category: Hilty C]]
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[[Category: Wuthrich, K.]]
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[[Category: Wider G]]
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[[Category: Detergent]]
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[[Category: Wuthrich K]]
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[[Category: Dhpc]]
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[[Category: Lipid]]
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[[Category: Membrane protein]]
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[[Category: Micelle]]
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[[Category: Nmr]]
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[[Category: Ompx]]
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[[Category: Trosy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:47:12 2009''
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Current revision

NMR STRUCTURE OF THE OUTER MEMBRANE PROTEIN OMPX IN DHPC MICELLES

PDB ID 1q9g

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