1ula

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:45, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ula.png|left|200px]]
 
-
<!--
+
==APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS==
-
The line below this paragraph, containing "STRUCTURE_1ula", creates the "Structure Box" on the page.
+
<StructureSection load='1ula' size='340' side='right'caption='[[1ula]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ula]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pnp 2pnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ULA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1ula| PDB=1ula | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ula FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ula OCA], [https://pdbe.org/1ula PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ula RCSB], [https://www.ebi.ac.uk/pdbsum/1ula PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ula ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ula_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ula ConSurf].
 +
<div style="clear:both"></div>
-
===APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS===
+
==See Also==
-
 
+
*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_1763067}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 1763067 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_1763067}}
+
-
 
+
-
==About this Structure==
+
-
1ULA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pnp 2pnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULA OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:1763067</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Purine-nucleoside phosphorylase]]
+
[[Category: Large Structures]]
-
[[Category: Babu, Y S.]]
+
[[Category: Babu YS]]
-
[[Category: Bugg, C E.]]
+
[[Category: Bugg CE]]
-
[[Category: Carter, D C.]]
+
[[Category: Carter DC]]
-
[[Category: Chen, S F.]]
+
[[Category: Chen S-F]]
-
[[Category: Cook, W J.]]
+
[[Category: Cook WJ]]
-
[[Category: Ealick, S E.]]
+
[[Category: Ealick SE]]
-
[[Category: Greenhough, T J.]]
+
[[Category: Greenhough TJ]]
-
[[Category: Habash, J.]]
+
[[Category: Habash J]]
-
[[Category: Helliwell, J R.]]
+
[[Category: Helliwell JR]]
-
[[Category: Parksjunior, R E.]]
+
[[Category: Parksjunior RE]]
-
[[Category: Rule, S A.]]
+
[[Category: Rule SA]]
-
[[Category: Stoeckler, J D.]]
+
[[Category: Stoeckler JD]]
-
[[Category: Pentosyltransferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:47:34 2009''
+

Current revision

APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS

PDB ID 1ula

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ula"
Personal tools