1yjo

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(New page: 200px<br /><applet load="1yjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yjo, resolution 1.30&Aring;" /> '''Structure of NNQQNY ...)
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[[Image:1yjo.gif|left|200px]]<br /><applet load="1yjo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yjo, resolution 1.30&Aring;" />
 
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'''Structure of NNQQNY from yeast prion Sup35 with zinc acetate'''<br />
 
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==Overview==
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==Structure of NNQQNY from yeast prion Sup35 with zinc acetate==
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Numerous soluble proteins convert to insoluble amyloid-like fibrils that, have common properties. Amyloid fibrils are associated with fatal diseases, such as Alzheimer's, and amyloid-like fibrils can be formed in vitro. For, the yeast protein Sup35, conversion to amyloid-like fibrils is associated, with a transmissible infection akin to that caused by mammalian prions. A, seven-residue peptide segment from Sup35 forms amyloid-like fibrils and, closely related microcrystals, from which we have determined the atomic, structure of the cross-beta spine. It is a double beta-sheet, with each, sheet formed from parallel segments stacked in register. Side chains, protruding from the two sheets form a dry, tightly self-complementing, steric zipper, bonding the sheets. Within each sheet, every segment is, bound to its two neighbouring segments through stacks of both backbone and, side-chain hydrogen bonds. The structure illuminates the stability of, amyloid fibrils, their self-seeding characteristic and their tendency to, form polymorphic structures.
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<StructureSection load='1yjo' size='340' side='right'caption='[[1yjo]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yjo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YJO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yjo OCA], [https://pdbe.org/1yjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yjo RCSB], [https://www.ebi.ac.uk/pdbsum/1yjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yjo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERF3_YEAST ERF3_YEAST] Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.<ref>PMID:7556078</ref> <ref>PMID:12923185</ref> <ref>PMID:15337765</ref>
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==About this Structure==
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==See Also==
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1YJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ZN and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YJO OCA].
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure of the cross-beta spine of amyloid-like fibrils., Nelson R, Sawaya MR, Balbirnie M, Madsen AO, Riekel C, Grothe R, Eisenberg D, Nature. 2005 Jun 9;435(7043):773-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15944695 15944695]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Balbirnie, M.]]
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[[Category: Large Structures]]
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[[Category: Eisenberg, D.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Grothe, R.]]
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[[Category: Balbirnie M]]
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[[Category: Madsen, A.O.]]
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[[Category: Eisenberg D]]
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[[Category: Nelson, R.]]
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[[Category: Grothe R]]
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[[Category: Riekel, C.]]
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[[Category: Madsen AO]]
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[[Category: Sawaya, M.R.]]
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[[Category: Nelson R]]
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[[Category: ACY]]
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[[Category: Riekel C]]
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[[Category: ZN]]
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[[Category: Sawaya MR]]
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[[Category: asparagine zipper]]
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[[Category: glutamine zipper]]
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[[Category: keywords beta sheet]]
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[[Category: steric zipper]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:50:41 2007''
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Current revision

Structure of NNQQNY from yeast prion Sup35 with zinc acetate

PDB ID 1yjo

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