1ny7

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{{Seed}}
 
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[[Image:1ny7.png|left|200px]]
 
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==COWPEA MOSAIC VIRUS (CPMV)==
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The line below this paragraph, containing "STRUCTURE_1ny7", creates the "Structure Box" on the page.
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<StructureSection load='1ny7' size='340' side='right'caption='[[1ny7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ny7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NY7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ny7 OCA], [https://pdbe.org/1ny7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ny7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ny7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ny7 ProSAT]</span></td></tr>
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{{STRUCTURE_1ny7| PDB=1ny7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POL2_CPMVS POL2_CPMVS] Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids. Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref> The cleavable C-terminus of small coat protein seems to be involved in the packaging of the virion RNAs. Also seems to act as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1ny7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ny7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Comoviruses are a group of plant viruses in the picornavirus superfamily. The type member of comoviruses, cowpea mosaic virus (CPMV), was crystallized in the cubic space group I23, a = 317 A and the hexagonal space group P6(1)22, a = 451 A, c = 1038 A. Structures of three closely similar nucleoprotein particles were determined in the cubic form. The roughly 300-A capsid was similar to the picornavirus capsid displaying a pseudo T = 3 (P = 3) surface lattice. The three beta-sandwich domains adopt two orientations, one with the long axis radial and the other two with the long axes tangential in reference to the capsid sphere. T = 3 viruses display one or the other of these two orientations. The CPMV capsid was permeable to cesium ions, leading to a disturbance of the beta-annulus inside a channel-like structure, suggesting an ion channel. The hexagonal crystal form diffracted X rays to 3 A resolution, despite the large unit cell. The large ( approximately 200 A) solvent channels in the lattice allow exchange of CPMV cognate Fab fragments. As an initial step in the structure determination of the CPMV/Fab complex, the P6(1)22 crystal structure was solved by molecular replacement with the CPMV model determined in the cubic cell.
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===COWPEA MOSAIC VIRUS (CPMV)===
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The refined crystal structure of cowpea mosaic virus at 2.8 A resolution.,Lin T, Chen Z, Usha R, Stauffacher CV, Dai JB, Schmidt T, Johnson JE Virology. 1999 Dec 5;265(1):20-34. PMID:10603314<ref>PMID:10603314</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ny7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10603314}}, adds the Publication Abstract to the page
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*[[Cowpea Chlorotic Mottle Virus|Cowpea Chlorotic Mottle Virus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10603314 is the PubMed ID number.
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_10603314}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1NY7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NY7 OCA].
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==Reference==
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<ref group="xtra">PMID:10603314</ref><references group="xtra"/>
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[[Category: Cowpea mosaic virus]]
[[Category: Cowpea mosaic virus]]
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[[Category: Chen, Z.]]
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[[Category: Large Structures]]
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[[Category: Dai, J B.]]
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[[Category: Chen Z]]
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[[Category: Johnson, J E.]]
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[[Category: Dai J-B]]
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[[Category: Lin, T.]]
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[[Category: Johnson JE]]
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[[Category: Schmidt, T.]]
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[[Category: Lin T]]
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[[Category: Stauffacher, C V.]]
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[[Category: Schmidt T]]
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[[Category: Usha, R.]]
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[[Category: Stauffacher CV]]
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[[Category: Comovirus]]
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[[Category: Usha R]]
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[[Category: Icosahedral virus]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:54:52 2009''
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Current revision

COWPEA MOSAIC VIRUS (CPMV)

PDB ID 1ny7

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