1u3m

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{{Seed}}
 
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[[Image:1u3m.png|left|200px]]
 
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==NMR structure of the chicken prion protein fragment 128-242==
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The line below this paragraph, containing "STRUCTURE_1u3m", creates the "Structure Box" on the page.
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<StructureSection load='1u3m' size='340' side='right'caption='[[1u3m]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3m OCA], [https://pdbe.org/1u3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3m RCSB], [https://www.ebi.ac.uk/pdbsum/1u3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3m ProSAT]</span></td></tr>
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{{STRUCTURE_1u3m| PDB=1u3m | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRIO_CHICK PRIO_CHICK]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structures of the recombinant prion proteins from chicken (Gallus gallus; chPrP), the red-eared slider turtle (Trachemys scripta; tPrP), and the African clawed frog (Xenopus laevis; xlPrP) are presented. The amino acid sequences of these prion proteins show approximately 30% identity with mammalian prion proteins. All three species form the same molecular architecture as mammalian PrPC, with a long, flexibly disordered tail attached to the N-terminal end of a globular domain. The globular domain in chPrP and tPrP contains three alpha-helices, one short 3(10)-helix, and a short antiparallel beta-sheet. In xlPrP, the globular domain includes three alpha-helices and a somewhat longer beta-sheet than in the other species. The spatial arrangement of these regular secondary structures coincides closely with that of the globular domain in mammalian prion proteins. Based on the low sequence identity to mammalian PrPs, comparison of chPrP, tPrP, and xlPrP with mammalian PrPC structures is used to identify a set of essential amino acid positions for the preservation of the same PrPC fold in birds, reptiles, amphibians, and mammals. There are additional conserved residues without apparent structural roles, which are of interest for the ongoing search for physiological functions of PrPC in healthy organisms.
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===NMR structure of the chicken prion protein fragment 128-242===
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Prion protein NMR structures of chickens, turtles, and frogs.,Calzolai L, Lysek DA, Perez DR, Guntert P, Wuthrich K Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):651-5. Epub 2005 Jan 12. PMID:15647366<ref>PMID:15647366</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1u3m" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15647366}}, adds the Publication Abstract to the page
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*[[Prion 3D structures|Prion 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15647366 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15647366}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1U3M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3M OCA].
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==Reference==
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<ref group="xtra">PMID:15647366</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Calzolai, L.]]
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[[Category: Large Structures]]
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[[Category: Guntert, P.]]
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[[Category: Calzolai L]]
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[[Category: Lysek, D A.]]
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[[Category: Guntert P]]
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[[Category: Wuthrich, K.]]
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[[Category: Lysek DA]]
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[[Category: Prion protein]]
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[[Category: Wuthrich K]]
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[[Category: Prp]]
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[[Category: Tse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:07:12 2009''
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Current revision

NMR structure of the chicken prion protein fragment 128-242

PDB ID 1u3m

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