2gvg

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{{Seed}}
 
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[[Image:2gvg.png|left|200px]]
 
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==Crystal Structure of human NMPRTase and its complex with NMN==
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The line below this paragraph, containing "STRUCTURE_2gvg", creates the "Structure Box" on the page.
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<StructureSection load='2gvg' size='340' side='right'caption='[[2gvg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gvg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GVG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2gvg| PDB=2gvg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gvg OCA], [https://pdbe.org/2gvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gvg RCSB], [https://www.ebi.ac.uk/pdbsum/2gvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gvg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/2gvg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gvg ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of human NMPRTase and its complex with NMN===
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16783377}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16783377 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16783377}}
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==About this Structure==
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2GVG is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVG OCA].
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==Reference==
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<ref group="xtra">PMID:16783377</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Khan, J A.]]
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[[Category: Khan JA]]
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[[Category: Tao, X.]]
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[[Category: Tao X]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Cancer]]
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[[Category: Crystal]]
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[[Category: Nmprtase]]
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[[Category: Pbef]]
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[[Category: Visfatin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:11:16 2009''
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Current revision

Crystal Structure of human NMPRTase and its complex with NMN

PDB ID 2gvg

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