3coo

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{{Seed}}
 
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[[Image:3coo.png|left|200px]]
 
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==The crystal structure of Reelin-N domain of F-spondin==
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The line below this paragraph, containing "STRUCTURE_3coo", creates the "Structure Box" on the page.
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<StructureSection load='3coo' size='340' side='right'caption='[[3coo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3coo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3coo OCA], [https://pdbe.org/3coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3coo RCSB], [https://www.ebi.ac.uk/pdbsum/3coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3coo ProSAT]</span></td></tr>
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{{STRUCTURE_3coo| PDB=3coo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPON1_HUMAN SPON1_HUMAN] Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3coo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3coo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The extracellular matrix protein F-spondin mediates axon guidance during neuronal development. Its N-terminal domain, termed the reelin-N domain, is conserved in F-spondins, reelins, and other extracellular matrix proteins. In this study, a recombinant human reelin-N domain has been expressed, purified, and shown to bind heparin. The crystal structure of the reelin-N domain resolved to 2.0 A reveals a variant immunoglobulin-like fold and potential heparin-binding sites. Substantial conformational variations even in secondary structure are observed between the two chemically identical reelin-N domains in one crystallographic asymmetric unit. The variations may result from extensive, highly specific interactions across the interface of the two reelin-N domains. The calculated values of buried surface area and the interface's shape complementarity are consistent with the formation of a weak dimer. The homophilic asymmetric dimer can potentially offer advantages in binding to ligands such as glycosaminoglycans, which may, in turn, bridge the two reelin-N domains and stabilize the dimer.
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===The crystal structure of Reelin-N domain of F-spondin===
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The crystal structure of the heparin-binding reelin-N domain of f-spondin.,Tan K, Duquette M, Liu JH, Lawler J, Wang JH J Mol Biol. 2008 Sep 19;381(5):1213-23. Epub 2008 Jun 24. PMID:18602404<ref>PMID:18602404</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18602404}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3coo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18602404 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18602404}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3COO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COO OCA].
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==Reference==
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<ref group="xtra">PMID:18602404</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lawler, J.]]
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[[Category: Large Structures]]
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[[Category: Tan, K.]]
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[[Category: Lawler J]]
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[[Category: Wang, J H.]]
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[[Category: Tan K]]
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[[Category: Cell adhesion]]
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[[Category: Wang JH]]
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[[Category: Extracellular matrix]]
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[[Category: F-spondin]]
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[[Category: Glycoprotein]]
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[[Category: Reelin-n domain]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:14:05 2009''
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Current revision

The crystal structure of Reelin-N domain of F-spondin

PDB ID 3coo

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