1q8k

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{{Seed}}
 
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[[Image:1q8k.png|left|200px]]
 
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==Solution structure of alpha subunit of human eIF2==
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The line below this paragraph, containing "STRUCTURE_1q8k", creates the "Structure Box" on the page.
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<StructureSection load='1q8k' size='340' side='right'caption='[[1q8k]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8k OCA], [https://pdbe.org/1q8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8k RCSB], [https://www.ebi.ac.uk/pdbsum/1q8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8k ProSAT]</span></td></tr>
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{{STRUCTURE_1q8k| PDB=1q8k | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF2A_HUMAN IF2A_HUMAN] Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8k ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The GTP-bound form of the trimeric eukaryotic translation initiation factor 2 (eIF2) transfers aminoacylated initiator methionyl tRNA onto the 40S ribosome. We have solved with solution NMR the structure of the alpha subunit of human eIF2 (heIF2alpha). The protein consists of two domains that are mobile relative to each other. The N-terminal domain has an S1-type oligonucleotide/oligosaccharide binding-fold subdomain and an alpha-helical subdomain. The C-terminal domain adopts an alphabeta-fold very similar to the C-terminal domain of elongation factor (eEF) 1Balpha, the guanine-nucleotide exchange factor for eEF1A. The structural and functional similarities found between eIF2alpha/eIF2gamma and eEF1Balpha/eEF1A suggest a model for the interaction of eIF2alpha with eIF2gamma, and eIF2 with Met-tRNAiMet. It further indicates a previously unrecognized evolutionary lineage of eIF2alpha/gamma from the functionally related elongation factor eEF1Balpha/eEF1A complex.
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===Solution structure of alpha subunit of human eIF2===
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Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.,Ito T, Marintchev A, Wagner G Structure. 2004 Sep;12(9):1693-704. PMID:15341733<ref>PMID:15341733</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1q8k" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15341733}}, adds the Publication Abstract to the page
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15341733 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15341733}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Q8K is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8K OCA].
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==Reference==
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<ref group="xtra">PMID:15341733</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ito, T.]]
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[[Category: Large Structures]]
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[[Category: Marintchev, A.]]
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[[Category: Ito T]]
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[[Category: Wagner, G.]]
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[[Category: Marintchev A]]
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[[Category: Eukaryotic translation initiation factor 2]]
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[[Category: Wagner G]]
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[[Category: Translation]]
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[[Category: Translation initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:17:12 2009''
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Current revision

Solution structure of alpha subunit of human eIF2

PDB ID 1q8k

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