1xs0

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{{Seed}}
 
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[[Image:1xs0.png|left|200px]]
 
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==Structure of the E. coli Ivy protein==
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The line below this paragraph, containing "STRUCTURE_1xs0", creates the "Structure Box" on the page.
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<StructureSection load='1xs0' size='340' side='right'caption='[[1xs0]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xs0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XS0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xs0 OCA], [https://pdbe.org/1xs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xs0 RCSB], [https://www.ebi.ac.uk/pdbsum/1xs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xs0 ProSAT]</span></td></tr>
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{{STRUCTURE_1xs0| PDB=1xs0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IVY_ECOLI IVY_ECOLI] Strong inhibitor of lysozyme C.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xs0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xs0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Part of an ancestral bactericidal system, vertebrate C-type lysozyme targets the peptidoglycan moiety of bacterial cell walls. We report the crystal structure of a protein inhibitor of C-type lysozyme, the Escherichia coli Ivy protein, alone and in complex with hen egg white lysozyme. Ivy exhibits a novel fold in which a protruding five-residue loop appears essential to its inhibitory effect. This feature guided the identification of Ivy orthologues in other Gram-negative bacteria. The structure of the evolutionary distant Pseudomonas aeruginosa Ivy orthologue was also determined in complex with hen egg white lysozyme, and its antilysozyme activity was confirmed. Ivy expression protects porous cell-wall E. coli mutants from the lytic effect of lysozyme, suggesting that it is a response against the permeabilizing effects of the innate vertebrate immune system. As such, Ivy acts as a virulence factor for a number of Gram-negative bacteria-infecting vertebrates.
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===Structure of the E. coli Ivy protein===
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Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria.,Abergel C, Monchois V, Byrne D, Chenivesse S, Lembo F, Lazzaroni JC, Claverie JM Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6394-9. Epub 2007 Apr 3. PMID:17405861<ref>PMID:17405861</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17405861}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1xs0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17405861 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17405861}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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1XS0 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XS0 OCA].
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[[Category: Large Structures]]
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[[Category: Abergel C]]
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==Reference==
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[[Category: Byrn D]]
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<ref group="xtra">PMID:17405861</ref><ref group="xtra">PMID:11278658</ref><ref group="xtra">PMID:11092949</ref><references group="xtra"/>
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[[Category: Claverie JM]]
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[[Category: Escherichia coli k12]]
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[[Category: Lazzaroni JC]]
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[[Category: Abergel, C.]]
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[[Category: Monchois V]]
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[[Category: Byrn, D.]]
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[[Category: Claverie, J M.]]
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[[Category: Lazzaroni, J C.]]
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[[Category: Monchois, V.]]
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[[Category: Alpha beta fold]]
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[[Category: Dimer]]
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[[Category: Hydrolase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:17:17 2009''
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Current revision

Structure of the E. coli Ivy protein

PDB ID 1xs0

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OCA

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