2dyj

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{{Seed}}
 
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[[Image:2dyj.png|left|200px]]
 
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==Crystal structure of ribosome-binding factor A from Thermus thermophilus HB8==
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The line below this paragraph, containing "STRUCTURE_2dyj", creates the "Structure Box" on the page.
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<StructureSection load='2dyj' size='340' side='right'caption='[[2dyj]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyj OCA], [https://pdbe.org/2dyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyj RCSB], [https://www.ebi.ac.uk/pdbsum/2dyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyj ProSAT], [https://www.topsan.org/Proteins/RSGI/2dyj TOPSAN]</span></td></tr>
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{{STRUCTURE_2dyj| PDB=2dyj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RBFA_THET8 RBFA_THET8] One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes) (PubMed:17996707). Required for efficient processing of 16S rRNA. Probably interacts with the 5'-terminal helix region of 16S rRNA, bringing together different domains of the 30S ribosomal subunit which aids assembly (PubMed:17996707).<ref>PMID:17996707</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribosome binding factor A (RbfA) is a bacterial cold shock response protein, required for an efficient processing of the 5' end of the 16S ribosomal RNA (rRNA) during assembly of the small (30S) ribosomal subunit. Here we present a crystal structure of Thermus thermophilus (Tth) RbfA and a three-dimensional cryo-electron microscopic (EM) map of the Tth 30S*RbfA complex. RbfA binds to the 30S subunit in a position overlapping the binding sites of the A and P site tRNAs, and RbfA's functionally important C terminus extends toward the 5' end of the 16S rRNA. In the presence of RbfA, a portion of the 16S rRNA encompassing helix 44, which is known to be directly involved in mRNA decoding and tRNA binding, is displaced. These results shed light on the role played by RbfA during maturation of the 30S subunit, and also indicate how RbfA provides cells with a translational advantage under conditions of cold shock.
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===Crystal structure of ribosome-binding factor A from Thermus thermophilus HB8===
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Structural aspects of RbfA action during small ribosomal subunit assembly.,Datta PP, Wilson DN, Kawazoe M, Swami NK, Kaminishi T, Sharma MR, Booth TM, Takemoto C, Fucini P, Yokoyama S, Agrawal RK Mol Cell. 2007 Nov 9;28(3):434-45. PMID:17996707<ref>PMID:17996707</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17996707}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2dyj" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17996707 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17996707}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2DYJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYJ OCA].
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[[Category: Thermus thermophilus HB8]]
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[[Category: Kawazoe M]]
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==Reference==
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[[Category: Nakayama-Ushikoshi R]]
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<ref group="xtra">PMID:17996707</ref><references group="xtra"/>
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[[Category: Shirouzu M]]
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[[Category: Thermus thermophilus]]
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[[Category: Takemoto C]]
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[[Category: Kawazoe, M.]]
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[[Category: Terada T]]
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[[Category: Nakayama-Ushikoshi, R.]]
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[[Category: Yokoyama S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu, M.]]
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[[Category: Takemoto, C.]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: 16s rrna processing]]
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[[Category: 17s rna]]
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[[Category: Kh domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Ribosomal protein]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:17:39 2009''
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Current revision

Crystal structure of ribosome-binding factor A from Thermus thermophilus HB8

PDB ID 2dyj

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