1o6t

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{{Seed}}
 
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[[Image:1o6t.png|left|200px]]
 
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==Internalin (INLA, Listeria monocytogenes) - functional domain, uncomplexed==
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The line below this paragraph, containing "STRUCTURE_1o6t", creates the "Structure Box" on the page.
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<StructureSection load='1o6t' size='340' side='right'caption='[[1o6t]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o6t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O6T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1o6t| PDB=1o6t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o6t OCA], [https://pdbe.org/1o6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o6t RCSB], [https://www.ebi.ac.uk/pdbsum/1o6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o6t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INLA_LISMO INLA_LISMO] Mediates the entry of L.monocytogenes into cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/1o6t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o6t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian cells by inducing its own phagocytosis. The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. We present the crystal structures of the functional domain of InlA alone and in a complex with the extracellular, N-terminal domain of human E-cadherin (hEC1). The leucine rich repeat (LRR) domain of InlA surrounds and specifically recognizes hEC1. Individual interactions were probed by mutagenesis and analytical ultracentrifugation. These include Pro16 of hEC1, a major determinant for human susceptibility to L. monocytogenes infection that is essential for intermolecular recognition. Our studies reveal the structural basis for host tro-pism of this bacterium and the molecular deception L. monocytogenes employs to exploit the E-cadherin system.
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===INTERNALIN (INLA,LISTERIA MONOCYTOGENES)- FUNCTIONAL DOMAIN,UNCOMPLEXED===
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Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.,Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW Cell. 2002 Dec 13;111(6):825-36. PMID:12526809<ref>PMID:12526809</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12526809}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1o6t" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12526809 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12526809}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1O6T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O6T OCA].
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Beier V]]
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==Reference==
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[[Category: Chakraborty T]]
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<ref group="xtra">PMID:12526809</ref><references group="xtra"/>
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[[Category: Domann E]]
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[[Category: Listeria monocytogenes]]
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[[Category: Heinz DW]]
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[[Category: Beier, V.]]
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[[Category: Machner MP]]
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[[Category: Chakraborty, T.]]
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[[Category: Schubert W-D]]
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[[Category: Domann, E.]]
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[[Category: Urbanke C]]
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[[Category: Heinz, D W.]]
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[[Category: Wehland J]]
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[[Category: Machner, M.]]
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[[Category: Ziehm T]]
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[[Category: Schubert, W D.]]
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[[Category: Urbanke, C.]]
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[[Category: Wehland, J.]]
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[[Category: Ziehm, T.]]
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[[Category: Bacterial infection]]
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[[Category: Cell adhesion]]
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[[Category: Cell-wall surface protein]]
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[[Category: Leucine rich repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:32:20 2009''
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Current revision

Internalin (INLA, Listeria monocytogenes) - functional domain, uncomplexed

PDB ID 1o6t

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