1btv

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{{Seed}}
 
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[[Image:1btv.png|left|200px]]
 
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==STRUCTURE OF BET V 1, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1btv", creates the "Structure Box" on the page.
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<StructureSection load='1btv' size='340' side='right'caption='[[1btv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BTV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [https://pdbe.org/1btv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [https://www.ebi.ac.uk/pdbsum/1btv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1btv ProSAT]</span></td></tr>
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{{STRUCTURE_1btv| PDB=1btv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/1btv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1btv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
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===STRUCTURE OF BET V 1, NMR, 20 STRUCTURES===
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X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858<ref>PMID:8946858</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8946858}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1btv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8946858 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8946858}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1BTV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA].
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==Reference==
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<ref group="xtra">PMID:8946858</ref><references group="xtra"/>
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[[Category: Betula pendula]]
[[Category: Betula pendula]]
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[[Category: Gajhede, M.]]
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[[Category: Large Structures]]
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[[Category: Larsen, J N.]]
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[[Category: Gajhede M]]
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[[Category: Osmark, P.]]
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[[Category: Larsen JN]]
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[[Category: Poulsen, F M.]]
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[[Category: Osmark P]]
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[[Category: Spangfort, M D.]]
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[[Category: Poulsen FM]]
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[[Category: Ige-allergy]]
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[[Category: Spangfort MD]]
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[[Category: Major birch pollen allergen]]
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[[Category: Pr-10 protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:33:14 2009''
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Current revision

STRUCTURE OF BET V 1, NMR, 20 STRUCTURES

PDB ID 1btv

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