1e5p

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{{Seed}}
 
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[[Image:1e5p.png|left|200px]]
 
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==Crystal structure of aphrodisin, a sex pheromone from female hamster==
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The line below this paragraph, containing "STRUCTURE_1e5p", creates the "Structure Box" on the page.
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<StructureSection load='1e5p' size='340' side='right'caption='[[1e5p]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1e5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E5P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1e5p| PDB=1e5p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5p OCA], [https://pdbe.org/1e5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e5p RCSB], [https://www.ebi.ac.uk/pdbsum/1e5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APHR_CRICR APHR_CRICR] Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/1e5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e5p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have solved the crystal structure of aphrodisin, a pheromonal protein inducing a copulatory behaviour in male hamster, using MAD methods with selenium, at 1.63 A resolution. The monomeric protein belongs to the lipocalin family, and possesses a disulfide bridge in a loop between strands 2 and 3. This disulfide bridge is characteristic of a family of lipocalins mainly identified in rodents, and is analogous to the fifth disulfide bridge of the long neurotoxins, such as alpha cobratoxin. An elongated electron density was found inside the buried cavity, which might represent a serendipitous ligand of unknown origin. The analysis of the water accessible surfaces of the side-chains bordering the cavity indicates that Phe76 may be the door for the natural ligand to access the cavity. This residue defines the entry of the cavity as belonging to the consensus for lipocalins. The face bearing Phe76 might also serve for the interaction with the receptor.
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===CRYSTAL STRUCTURE OF APHRODISIN, A SEX PHEROMONE FROM FEMALE HAMSTER===
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Crystal structure of aphrodisin, a sex pheromone from female hamster.,Vincent F, Lobel D, Brown K, Spinelli S, Grote P, Breer H, Cambillau C, Tegoni M J Mol Biol. 2001 Jan 19;305(3):459-69. PMID:11152604<ref>PMID:11152604</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11152604}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1e5p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11152604 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11152604}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1E5P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA].
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==Reference==
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<ref group="xtra">PMID:11152604</ref><references group="xtra"/>
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[[Category: Mesocricetus auratus]]
[[Category: Mesocricetus auratus]]
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[[Category: Brown, K.]]
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[[Category: Brown K]]
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[[Category: Cambillau, C.]]
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[[Category: Cambillau C]]
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[[Category: Spinelli, S.]]
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[[Category: Spinelli S]]
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[[Category: Tegoni, M.]]
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[[Category: Tegoni M]]
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[[Category: Vincent, F.]]
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[[Category: Vincent F]]
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[[Category: Crystal structure]]
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[[Category: Hamster]]
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[[Category: Lipocalin]]
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[[Category: Pheromone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:33:30 2009''
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Current revision

Crystal structure of aphrodisin, a sex pheromone from female hamster

PDB ID 1e5p

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