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1ypn
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1ypn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ypn, resolution 2.3Å" /> '''REDUCED FORM HYDROXYM...) |
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| - | [[Image:1ypn.jpg|left|200px]]<br /><applet load="1ypn" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1ypn, resolution 2.3Å" /> | ||
| - | '''REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION'''<br /> | ||
| - | == | + | ==REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION== |
| - | + | <StructureSection load='1ypn' size='340' side='right'caption='[[1ypn]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[1ypn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YPN FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ypn OCA], [https://pdbe.org/1ypn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ypn RCSB], [https://www.ebi.ac.uk/pdbsum/1ypn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ypn ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260] |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1ypn_consurf.spt"</scriptWhenChecked> | |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [ | + | </jmolCheckbox> |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ypn ConSurf]. |
| - | [ | + | <div style="clear:both"></div> |
| - | + | ==See Also== | |
| + | *[[Porphobilinogen Deaminase|Porphobilinogen Deaminase]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carr PD]] | ||
| + | [[Category: Cassetta A]] | ||
| + | [[Category: Habash J]] | ||
| + | [[Category: Haedener A]] | ||
| + | [[Category: Helliwell JR]] | ||
| + | [[Category: Nieh YP]] | ||
| + | [[Category: Niemann AC]] | ||
| + | [[Category: Raftery J]] | ||
| + | [[Category: Thompson AW]] | ||
| + | [[Category: Ursby T]] | ||
| + | [[Category: Wulff M]] | ||
Current revision
REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION
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Categories: Escherichia coli | Large Structures | Carr PD | Cassetta A | Habash J | Haedener A | Helliwell JR | Nieh YP | Niemann AC | Raftery J | Thompson AW | Ursby T | Wulff M
