2rgt

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{{Seed}}
 
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[[Image:2rgt.png|left|200px]]
 
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==Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1==
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The line below this paragraph, containing "STRUCTURE_2rgt", creates the "Structure Box" on the page.
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<StructureSection load='2rgt' size='340' side='right'caption='[[2rgt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RGT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2rgt| PDB=2rgt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rgt OCA], [https://pdbe.org/2rgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rgt RCSB], [https://www.ebi.ac.uk/pdbsum/2rgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rgt ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1===
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== Function ==
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[https://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.[https://www.uniprot.org/uniprot/LHX3_MOUSE LHX3_MOUSE] Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pou1f1/Pit-1.<ref>PMID:10593900</ref> <ref>PMID:12150931</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18583962}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18583962 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/2rgt_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18583962}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2RGT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RGT OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rgt ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:18583962</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bhati, M.]]
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[[Category: Synthetic construct]]
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[[Category: Guss, J M.]]
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[[Category: Bhati M]]
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[[Category: Lee, M.]]
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[[Category: Guss JM]]
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[[Category: Matthews, J M.]]
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[[Category: Lee M]]
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[[Category: Activator]]
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[[Category: Matthews JM]]
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[[Category: Alternative splicing]]
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[[Category: Dna-binding]]
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[[Category: Homeobox]]
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[[Category: Lim domain]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Protein-protein complex]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:52:49 2009''
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Current revision

Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1

PDB ID 2rgt

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