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1cvu

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{{Seed}}
 
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[[Image:1cvu.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2==
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The line below this paragraph, containing "STRUCTURE_1cvu", creates the "Structure Box" on the page.
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<StructureSection load='1cvu' size='340' side='right'caption='[[1cvu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1cvu| PDB=1cvu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvu OCA], [https://pdbe.org/1cvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvu RCSB], [https://www.ebi.ac.uk/pdbsum/1cvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cvu ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2===
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==See Also==
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10811226}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10811226 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_10811226}}
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==About this Structure==
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1CVU is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVU OCA].
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==Reference==
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<ref group="xtra">PMID:10811226</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Gierse JK]]
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[[Category: Gierse, J K.]]
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[[Category: Goodwin DC]]
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[[Category: Goodwin, D C.]]
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[[Category: Kiefer JR]]
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[[Category: Kiefer, J R.]]
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[[Category: Kurumbail RG]]
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[[Category: Kurumbail, R G.]]
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[[Category: Marnett LJ]]
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[[Category: Marnett, L J.]]
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[[Category: Moreland KT]]
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[[Category: Moreland, K T.]]
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[[Category: Pawlitz JL]]
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[[Category: Pawlitz, J L.]]
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[[Category: Rowlinson SW]]
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[[Category: Rowlinson, S W.]]
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[[Category: Stallings WC]]
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[[Category: Stallings, W C.]]
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[[Category: Stegeman RA]]
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[[Category: Stegeman, R A.]]
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[[Category: Stevens AM]]
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[[Category: Stevens, A M.]]
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[[Category: Arachidonate]]
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[[Category: Cox-2]]
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[[Category: Cyclooxygenase]]
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[[Category: Endoperoxide]]
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[[Category: Prostaglandin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:54:59 2009''
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Current revision

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

PDB ID 1cvu

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