2z5f

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{{Seed}}
 
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[[Image:2z5f.png|left|200px]]
 
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==Human sulfotransferase Sult1b1 in complex with PAP==
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The line below this paragraph, containing "STRUCTURE_2z5f", creates the "Structure Box" on the page.
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<StructureSection load='2z5f' size='340' side='right'caption='[[2z5f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xv1 1xv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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{{STRUCTURE_2z5f| PDB=2z5f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5f OCA], [https://pdbe.org/2z5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5f RCSB], [https://www.ebi.ac.uk/pdbsum/2z5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5f ConSurf].
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<div style="clear:both"></div>
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===Human sulfotransferase Sult1b1 in complex with PAP===
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2Z5F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xv1 1xv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5F OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:16804942</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dombrovski, L.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Dombrovski L]]
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[[Category: Loppnau, P.]]
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[[Category: Edwards AM]]
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[[Category: Pegasova, T.]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A N.]]
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[[Category: Pegasova T]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Plotnikov AN]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Pap]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Sulfotransferase]]
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[[Category: Sult]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:08:42 2009''
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Current revision

Human sulfotransferase Sult1b1 in complex with PAP

PDB ID 2z5f

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