3b2r

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{{Seed}}
 
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[[Image:3b2r.png|left|200px]]
 
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==Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil==
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The line below this paragraph, containing "STRUCTURE_3b2r", creates the "Structure Box" on the page.
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<StructureSection load='3b2r' size='340' side='right'caption='[[3b2r]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B2R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VDN:2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE'>VDN</scene></td></tr>
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{{STRUCTURE_3b2r| PDB=3b2r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2r OCA], [https://pdbe.org/3b2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b2r RCSB], [https://www.ebi.ac.uk/pdbsum/3b2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b2r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/3b2r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b2r ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17959709}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17959709 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17959709}}
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==About this Structure==
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3B2R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B2R OCA].
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==Reference==
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<ref group="xtra">PMID:17959709</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hengming, K.]]
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[[Category: Large Structures]]
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[[Category: Howard, R.]]
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[[Category: Hengming K]]
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[[Category: Huanchen, W.]]
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[[Category: Howard R]]
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[[Category: Mengchun, Y.]]
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[[Category: Huanchen W]]
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[[Category: Sharron, H F.]]
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[[Category: Mengchun Y]]
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[[Category: Allosteric enzyme]]
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[[Category: Sharron HF]]
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[[Category: Alternative splicing]]
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[[Category: Cgmp phosphodiesterase]]
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[[Category: Cgmp-binding]]
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[[Category: Hydrolase]]
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[[Category: Levitratm.]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Pde5-inhibitor potency]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Sildenafil]]
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[[Category: Vardenafil]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:14:04 2009''
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Current revision

Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil

PDB ID 3b2r

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