1rhw

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{{Seed}}
 
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[[Image:1rhw.png|left|200px]]
 
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==The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila==
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The line below this paragraph, containing "STRUCTURE_1rhw", creates the "Structure Box" on the page.
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<StructureSection load='1rhw' size='340' side='right'caption='[[1rhw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rhw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RHW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rhw OCA], [https://pdbe.org/1rhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rhw RCSB], [https://www.ebi.ac.uk/pdbsum/1rhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rhw ProSAT]</span></td></tr>
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{{STRUCTURE_1rhw| PDB=1rhw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME] Acts as a non-catalytic accessory component of a dynein complex (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/1rhw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rhw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of Drosophila LC8 pH-induced monomer has been determined by NMR spectroscopy using the program AutoStructure. The structure at pH 3 and 30 degrees C is similar to the individual subunits of mammalian LC8 dimer with the exception that a beta strand, which crosses between monomers to form an intersubunit beta-sheet in the dimer, is a flexible loop with turnlike conformations in the monomer. Increased flexibility in the interface region relative to the rest of the protein is confirmed by dynamic measurements based on (15)N relaxation. Comparison of the monomer and dimer structures indicates that LC8 is not a domain swapped dimer.
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===The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila===
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The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila.,Makokha M, Huang YJ, Montelione G, Edison AS, Barbar E Protein Sci. 2004 Mar;13(3):727-34. Epub 2004 Feb 6. PMID:14767079<ref>PMID:14767079</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1rhw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14767079}}, adds the Publication Abstract to the page
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*[[Dynein 3D structures|Dynein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14767079 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14767079}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1RHW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RHW OCA].
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==Reference==
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<ref group="xtra">PMID:14767079</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Barbar, E.]]
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[[Category: Large Structures]]
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[[Category: Edison, A S.]]
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[[Category: Barbar E]]
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[[Category: Huang, Y J.]]
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[[Category: Edison AS]]
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[[Category: Makokha, M.]]
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[[Category: Huang YJ]]
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[[Category: Montelione, G.]]
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[[Category: Makokha M]]
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[[Category: Dimer interface]]
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[[Category: Montelione G]]
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[[Category: Domain swapped]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:15:26 2009''
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Current revision

The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila

PDB ID 1rhw

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