1yvm

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(New page: 200px<br /><applet load="1yvm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yvm, resolution 1.60&Aring;" /> '''E. coli Methionine A...)
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[[Image:1yvm.gif|left|200px]]<br /><applet load="1yvm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yvm, resolution 1.60&Aring;" />
 
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'''E. coli Methionine Aminopeptidase in complex with thiabendazole'''<br />
 
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==About this Structure==
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==E. coli Methionine Aminopeptidase in complex with thiabendazole==
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1YVM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CO, NA and TMG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YVM OCA].
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<StructureSection load='1yvm' size='340' side='right'caption='[[1yvm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yvm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMG:2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE'>TMG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvm OCA], [https://pdbe.org/1yvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvm RCSB], [https://www.ebi.ac.uk/pdbsum/1yvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvm ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assays., Schiffmann R, Heine A, Klebe G, Klein CD, Angew Chem Int Ed Engl. 2005 Jun 6;44(23):3620-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15880695 15880695]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methionyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Heine A]]
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[[Category: Heine, A.]]
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[[Category: Klebe G]]
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[[Category: Klebe, G.]]
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[[Category: Klein CD]]
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[[Category: Klein, C.D.]]
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[[Category: Schiffmann R]]
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[[Category: Schiffmann, R.]]
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[[Category: CO]]
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[[Category: NA]]
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[[Category: TMG]]
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[[Category: hydrolase(alpha-aminoacylpeptide)]]
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[[Category: inhibitor]]
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[[Category: metal complex]]
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[[Category: methionine aminopeptidase]]
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[[Category: thiabendazole]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:05:04 2007''
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Current revision

E. coli Methionine Aminopeptidase in complex with thiabendazole

PDB ID 1yvm

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