2qd4

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{{Seed}}
 
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[[Image:2qd4.png|left|200px]]
 
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==Wild type human ferrochelatase crystallized with MnCl2==
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The line below this paragraph, containing "STRUCTURE_2qd4", creates the "Structure Box" on the page.
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<StructureSection load='2qd4' size='340' side='right'caption='[[2qd4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QD4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2qd4| PDB=2qd4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qd4 OCA], [https://pdbe.org/2qd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qd4 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[https://omim.org/entry/177000 177000]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref> <ref>PMID:1376018</ref> <ref>PMID:7910885</ref> <ref>PMID:8757534</ref> <ref>PMID:9585598</ref> <ref>PMID:9740232</ref> <ref>PMID:10942404</ref> <ref>PMID:11375302</ref> <ref>PMID:12063482</ref> <ref>PMID:12601550</ref> <ref>PMID:15286165</ref> <ref>PMID:17196862</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN] Catalyzes the ferrous insertion into protoporphyrin IX.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/2qd4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qd4 ConSurf].
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<div style="clear:both"></div>
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===Wild type human ferrochelatase crystallized with MnCl2===
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==See Also==
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*[[Ferrochelatase 3D structures|Ferrochelatase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_17884090}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17884090 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17884090}}
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==Disease==
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Known disease associated with this structure: Protoporphyria, erythropoietic, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612386 612386]], Protoporphyria, erythropoietic, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612386 612386]]
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==About this Structure==
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2QD4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QD4 OCA].
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==Reference==
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<ref group="xtra">PMID:17884090</ref><references group="xtra"/>
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[[Category: Ferrochelatase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dailey, H A.]]
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[[Category: Large Structures]]
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[[Category: Dailey, T A.]]
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[[Category: Dailey HA]]
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[[Category: Lanzilotta, W N.]]
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[[Category: Dailey TA]]
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[[Category: Medlock, A E.]]
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[[Category: Lanzilotta WN]]
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[[Category: Ross, T A.]]
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[[Category: Medlock AE]]
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[[Category: Ferrochelatase]]
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[[Category: Ross TA]]
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[[Category: Heme synthesis]]
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[[Category: Lyase]]
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[[Category: Protoporphyrin ix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:18:30 2009''
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Current revision

Wild type human ferrochelatase crystallized with MnCl2

PDB ID 2qd4

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