1t74

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[[Image:1t74.png|left|200px]]
 
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==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif==
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The line below this paragraph, containing "STRUCTURE_1t74", creates the "Structure Box" on the page.
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<StructureSection load='1t74' size='340' side='right'caption='[[1t74]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T74 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1t74| PDB=1t74 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t74 OCA], [https://pdbe.org/1t74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t74 RCSB], [https://www.ebi.ac.uk/pdbsum/1t74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t74 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t74_consurf.spt"</scriptWhenChecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t74 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif===
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==See Also==
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*[[Androgen receptor 3D structures|Androgen receptor 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15328534 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15328534}}
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==About this Structure==
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1T74 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T74 OCA].
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==Reference==
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<ref group="xtra">PMID:15328534</ref><references group="xtra"/>
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[[Category: Pan troglodytes]]
[[Category: Pan troglodytes]]
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[[Category: Buehrer, B M.]]
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[[Category: Buehrer BM]]
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[[Category: Fletterick, R J.]]
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[[Category: Fletterick RJ]]
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[[Category: Gron, H.]]
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[[Category: Gron H]]
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[[Category: Hur, E.]]
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[[Category: Hur E]]
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[[Category: Payne, E S.]]
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[[Category: Payne ES]]
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[[Category: Pfaff, S J.]]
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[[Category: Pfaff SJ]]
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[[Category: Af-2]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Androgen]]
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[[Category: Dht]]
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[[Category: Ligand binding domain]]
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[[Category: Nuclear receptor]]
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[[Category: Testosterone]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:19:14 2009''
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Current revision

Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif

PDB ID 1t74

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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