1k3k

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{{Seed}}
 
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[[Image:1k3k.png|left|200px]]
 
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==Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus==
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The line below this paragraph, containing "STRUCTURE_1k3k", creates the "Structure Box" on the page.
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<StructureSection load='1k3k' size='340' side='right'caption='[[1k3k]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K3K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [https://pdbe.org/1k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB], [https://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3k ProSAT]</span></td></tr>
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{{STRUCTURE_1k3k| PDB=1k3k | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q76RI8_HHV8 Q76RI8_HHV8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/1k3k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k3k ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. &amp; Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. &amp; Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
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===Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus===
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Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.,Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405<ref>PMID:11904405</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11904405}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1k3k" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11904405 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11904405}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human gammaherpesvirus 8]]
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1K3K is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA].
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[[Category: Large Structures]]
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[[Category: Fesik SW]]
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==Reference==
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[[Category: Huang Q]]
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<ref group="xtra">PMID:11904405</ref><references group="xtra"/>
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[[Category: Olejniczak ET]]
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[[Category: Human herpesvirus 8]]
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[[Category: Petros AM]]
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[[Category: Fesik, S W.]]
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[[Category: Virgin HW]]
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[[Category: Huang, Q.]]
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[[Category: Olejniczak, E T.]]
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[[Category: Petros, A M.]]
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[[Category: Virgin, H W.]]
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[[Category: Bcl-2]]
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[[Category: Herpesvirus]]
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[[Category: Nmr]]
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[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:21:55 2009''
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Current revision

Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus

PDB ID 1k3k

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