2lbd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:04, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2lbd.png|left|200px]]
 
-
<!--
+
==LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID==
-
The line below this paragraph, containing "STRUCTURE_2lbd", creates the "Structure Box" on the page.
+
<StructureSection load='2lbd' size='340' side='right'caption='[[2lbd]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2lbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBD FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
-
{{STRUCTURE_2lbd| PDB=2lbd | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbd OCA], [https://pdbe.org/2lbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbd RCSB], [https://www.ebi.ac.uk/pdbsum/2lbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbd ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RARG_HUMAN RARG_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/2lbd_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2lbd ConSurf].
 +
<div style="clear:both"></div>
-
===LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID===
+
==See Also==
-
 
+
*[[Retinoic acid receptor|Retinoic acid receptor]]
-
 
+
*[[Retinoic acid receptor 3D structures|Retinoic acid receptor 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_7501014}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 7501014 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_7501014}}
+
-
 
+
-
==About this Structure==
+
-
2LBD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBD OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:7501014</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Moras, D.]]
+
[[Category: Large Structures]]
-
[[Category: Renaud, J P.]]
+
[[Category: Moras D]]
-
[[Category: Rochel, N.]]
+
[[Category: Renaud J-P]]
-
[[Category: Ruff, M.]]
+
[[Category: Rochel N]]
-
[[Category: SPINE, Structural Proteomics in Europe.]]
+
[[Category: Ruff M]]
-
[[Category: Active conformation]]
+
-
[[Category: All-trans retinoic acid]]
+
-
[[Category: Complex]]
+
-
[[Category: Holo form]]
+
-
[[Category: Ligand-binding domain]]
+
-
[[Category: Ligand-dependent]]
+
-
[[Category: Nuclear receptor]]
+
-
[[Category: Retinoic acid receptor]]
+
-
[[Category: Spine]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural proteomics in europe]]
+
-
[[Category: Transcription regulation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:26:33 2009''
+

Current revision

LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID

PDB ID 2lbd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lbd"
Personal tools