2f9k

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{{Seed}}
 
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[[Image:2f9k.png|left|200px]]
 
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==Crystal structure of human FPPS in complex with Zoledronate and Zn2+==
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The line below this paragraph, containing "STRUCTURE_2f9k", creates the "Structure Box" on the page.
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<StructureSection load='2f9k' size='340' side='right'caption='[[2f9k]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F9K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene></td></tr>
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{{STRUCTURE_2f9k| PDB=2f9k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9k OCA], [https://pdbe.org/2f9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f9k RCSB], [https://www.ebi.ac.uk/pdbsum/2f9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f9k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f9k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f9k ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human FPPS in complex with Zoledronate and Zn2+===
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16892359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16892359}}
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==About this Structure==
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2F9K is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA].
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==Reference==
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<ref group="xtra">PMID:16892359</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bitsch, F.]]
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[[Category: Large Structures]]
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[[Category: Bourgier, E.]]
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[[Category: Bitsch F]]
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[[Category: Geiser, M.]]
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[[Category: Bourgier E]]
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[[Category: Green, J R.]]
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[[Category: Geiser M]]
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[[Category: Hemmig, R.]]
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[[Category: Green JR]]
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[[Category: Jahnke, W.]]
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[[Category: Hemmig R]]
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[[Category: Kroemer, M.]]
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[[Category: Jahnke W]]
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[[Category: Lehmann, S.]]
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[[Category: Kroemer M]]
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[[Category: Ramage, P.]]
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[[Category: Lehmann S]]
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[[Category: Rieffel, S.]]
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[[Category: Ramage P]]
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[[Category: Rondeau, J M.]]
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[[Category: Rieffel S]]
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[[Category: Strauss, A.]]
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[[Category: Rondeau J-M]]
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[[Category: Bisphosphonate inhibitor]]
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[[Category: Strauss A]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Mevalonate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:27:55 2009''
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Current revision

Crystal structure of human FPPS in complex with Zoledronate and Zn2+

PDB ID 2f9k

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