1uiz

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{{Seed}}
 
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[[Image:1uiz.png|left|200px]]
 
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==Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.==
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The line below this paragraph, containing "STRUCTURE_1uiz", creates the "Structure Box" on the page.
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<StructureSection load='1uiz' size='340' side='right'caption='[[1uiz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UIZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uiz OCA], [https://pdbe.org/1uiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uiz RCSB], [https://www.ebi.ac.uk/pdbsum/1uiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uiz ProSAT]</span></td></tr>
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{{STRUCTURE_1uiz| PDB=1uiz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIF_XENLA MIF_XENLA] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Required for normal neural development during embryogenesis.[UniProtKB:P14174]<ref>PMID:15024012</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1uiz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uiz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine involved in both acquired and innate immunity. MIF also has many functions outside the immune system, such as isomerase and oxidoreductase activities and control of cell proliferation. Considering the involvement of MIF in various intra- and extracellular events, we expected that MIF might also be important in vertebrate development. To elucidate the possible role of MIF in developmental processes, we knocked down MIF in embryos of the African clawed frog Xenopus laevis, using MIF-specific morpholino oligomers (MOs). For the synthesis of the MOs, we cloned a cDNA for a Xenopus homolog of MIF. Sequence analysis, determination of the isomerase activity, and x-ray crystallographic analysis revealed that the protein encoded by the cDNA was the ortholog of mammalian MIF. We carried out whole mount in situ hybridization of MIF mRNA and found that MIF was expressed at high levels in the neural tissues of normal embryos. Although early embryogenesis of MO-injected embryos proceeded normally until the gastrula stage, their neurulation was completely inhibited. At the tailbud stage, the MO-injected embryos lacked neural and mesodermal tissues, and also showed severe defects in their head and tail structures. Thus, MIF was found to be essential for axis formation and neural development of Xenopus embryos.
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===Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.===
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Xenopus laevis macrophage migration inhibitory factor is essential for axis formation and neural development.,Suzuki M, Takamura Y, Maeno M, Tochinai S, Iyaguchi D, Tanaka I, Nishihira J, Ishibashi T J Biol Chem. 2004 May 14;279(20):21406-14. Epub 2004 Mar 15. PMID:15024012<ref>PMID:15024012</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1uiz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15024012}}, adds the Publication Abstract to the page
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*[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15024012 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15024012}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1UIZ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UIZ OCA].
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==Reference==
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<ref group="xtra">PMID:15024012</ref><references group="xtra"/>
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[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Ishibashi, T.]]
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[[Category: Ishibashi T]]
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[[Category: Iyaguchi, D.]]
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[[Category: Iyaguchi D]]
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[[Category: Maeno, M.]]
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[[Category: Maeno M]]
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[[Category: Nishihira, J.]]
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[[Category: Nishihira J]]
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[[Category: Suzuki, M.]]
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[[Category: Suzuki M]]
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[[Category: Takamura, Y.]]
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[[Category: Takamura Y]]
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[[Category: Tanaka, I.]]
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[[Category: Tanaka I]]
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[[Category: Tochinai, S.]]
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[[Category: Tochinai S]]
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[[Category: Cytokine]]
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[[Category: Macrophage migration inhibitory factor]]
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[[Category: Mif]]
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[[Category: Tautomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:29:37 2009''
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Current revision

Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.

PDB ID 1uiz

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