2hvz

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{{Seed}}
 
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[[Image:2hvz.png|left|200px]]
 
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==Solution structure of the RRM domain of SR rich factor 9G8==
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The line below this paragraph, containing "STRUCTURE_2hvz", creates the "Structure Box" on the page.
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<StructureSection load='2hvz' size='340' side='right'caption='[[2hvz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HVZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvz OCA], [https://pdbe.org/2hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hvz RCSB], [https://www.ebi.ac.uk/pdbsum/2hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hvz ProSAT]</span></td></tr>
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{{STRUCTURE_2hvz| PDB=2hvz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRSF7_HUMAN SRSF7_HUMAN] Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.<ref>PMID:11336712</ref> <ref>PMID:12667464</ref> <ref>PMID:15009664</ref> <ref>PMID:18364396</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/2hvz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hvz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.
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===Solution structure of the RRM domain of SR rich factor 9G8===
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Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.,Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:17036044<ref>PMID:17036044</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17036044}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2hvz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17036044}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2HVZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA].
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==Reference==
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<ref group="xtra">PMID:17036044</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Golovanov, A P.]]
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[[Category: Large Structures]]
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[[Category: Hautbergue, G M.]]
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[[Category: Golovanov AP]]
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[[Category: Lian, L Y.]]
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[[Category: Hautbergue GM]]
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[[Category: Tintaru, A M.]]
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[[Category: Lian LY]]
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[[Category: Wilson, S A.]]
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[[Category: Tintaru AM]]
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[[Category: Rrm]]
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[[Category: Wilson SA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:32:56 2009''
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Current revision

Solution structure of the RRM domain of SR rich factor 9G8

PDB ID 2hvz

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