1l1l

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{{Seed}}
 
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[[Image:1l1l.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE==
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The line below this paragraph, containing "STRUCTURE_1l1l", creates the "Structure Box" on the page.
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<StructureSection load='1l1l' size='340' side='right'caption='[[1l1l]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactobacillus_leichmannii Lactobacillus leichmannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1l OCA], [https://pdbe.org/1l1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1l RCSB], [https://www.ebi.ac.uk/pdbsum/1l1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1l ProSAT]</span></td></tr>
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{{STRUCTURE_1l1l| PDB=1l1l | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RTPR_LACLE RTPR_LACLE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1l ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides, an essential step in DNA biosynthesis and repair. Here we present the crystal structure of class II (coenzyme B12-dependent) ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannii in the apo enzyme form and in complex with the B12 analog adeninylpentylcobalamin at 1.75 and 2.0 A resolution, respectively. This monomeric, allosterically regulated class II RNR retains all the key structural features associated with the catalytic and regulatory machinery of oligomeric RNRs. Surprisingly, the dimer interface responsible for effector binding in class I RNR is preserved through a single 130-residue insertion in the class II structure. Thus, L. leichmannii RNR is a paradigm for the simplest structural entity capable of ribonucleotide reduction, a reaction linking the RNA and DNA worlds.
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===CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE===
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The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer.,Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL Nat Struct Biol. 2002 Apr;9(4):293-300. PMID:11875520<ref>PMID:11875520</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1l1l" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11875520}}, adds the Publication Abstract to the page
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11875520 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11875520}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1L1L is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Lactobacillus_leichmannii Lactobacillus leichmannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1L OCA].
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==Reference==
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<ref group="xtra">PMID:11875520</ref><references group="xtra"/>
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[[Category: Lactobacillus leichmannii]]
[[Category: Lactobacillus leichmannii]]
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[[Category: Ribonucleoside-triphosphate reductase]]
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[[Category: Large Structures]]
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[[Category: Arjara, G.]]
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[[Category: Arjara G]]
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[[Category: Drennan, C L.]]
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[[Category: Drennan CL]]
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[[Category: Kellogg, B A.]]
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[[Category: Kellogg BA]]
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[[Category: Sintchak, M D.]]
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[[Category: Sintchak MD]]
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[[Category: Stubbe, J.]]
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[[Category: Stubbe J]]
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[[Category: 10-stranded alpha-beta barrel]]
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[[Category: Central finger loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:35:07 2009''
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Current revision

CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE

PDB ID 1l1l

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