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1dle

From Proteopedia

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{{Seed}}
 
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[[Image:1dle.png|left|200px]]
 
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==FACTOR B SERINE PROTEASE DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1dle", creates the "Structure Box" on the page.
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<StructureSection load='1dle' size='340' side='right'caption='[[1dle]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dle OCA], [https://pdbe.org/1dle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dle RCSB], [https://www.ebi.ac.uk/pdbsum/1dle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dle ProSAT]</span></td></tr>
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{{STRUCTURE_1dle| PDB=1dle | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[https://omim.org/entry/612924 612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dle_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dle ConSurf].
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<div style="clear:both"></div>
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===FACTOR B SERINE PROTEASE DOMAIN===
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==See Also==
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*[[Complement factor 3D structures|Complement factor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10637221 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10637221}}
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==About this Structure==
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1DLE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLE OCA].
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==Reference==
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<ref group="xtra">PMID:10637221</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carson, M.]]
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[[Category: Large Structures]]
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[[Category: Jing, H.]]
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[[Category: Carson M]]
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[[Category: Macon, K J.]]
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[[Category: Jing H]]
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[[Category: Moore, D.]]
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[[Category: Macon KJ]]
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[[Category: Narayana, S V.]]
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[[Category: Moore D]]
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[[Category: Volanakis, J E.]]
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[[Category: Narayana SV]]
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[[Category: Xu, Y.]]
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[[Category: Volanakis JE]]
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[[Category: Activation mechanism]]
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[[Category: Xu Y]]
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[[Category: Beta-barrel fold]]
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[[Category: Complement system]]
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[[Category: Factor b]]
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[[Category: Protein-protein interaction]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:38:56 2009''
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Current revision

FACTOR B SERINE PROTEASE DOMAIN

PDB ID 1dle

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