2j38

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:05, 21 November 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2j38.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX==
-
The line below this paragraph, containing "STRUCTURE_2j38", creates the "Structure Box" on the page.
+
<StructureSection load='2j38' size='340' side='right'caption='[[2j38]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2j38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J38 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GS5:5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE'>GS5</scene></td></tr>
-
{{STRUCTURE_2j38| PDB=2j38 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j38 OCA], [https://pdbe.org/2j38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j38 RCSB], [https://www.ebi.ac.uk/pdbsum/2j38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j38 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j38_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j38 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Torsional scans of sulfonamide S-C bonds in small model systems of a series of arylsulfonamide factor Xa inhibitors were performed in order to investigate if conformational effects can help to rationalise the observed SAR. Computational results were in good agreement with the experimental data indicating that the sulfonamide conformation plays an important role in determining the activity in this particular series of factor Xa inhibitors.
-
===CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX===
+
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors.,Senger S, Convery MA, Chan C, Watson NS Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192<ref>PMID:16982192</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2j38" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16982192}}, adds the Publication Abstract to the page
+
*[[Factor Xa|Factor Xa]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16982192 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16982192}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2J38 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J38 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16982192</ref><references group="xtra"/>
+
-
[[Category: Coagulation factor Xa]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chan, C.]]
+
[[Category: Large Structures]]
-
[[Category: Convery, M A.]]
+
[[Category: Chan C]]
-
[[Category: Senger, S.]]
+
[[Category: Convery MA]]
-
[[Category: Watson, N S.]]
+
[[Category: Senger S]]
-
[[Category: Blood coagulation]]
+
[[Category: Watson NS]]
-
[[Category: Calcium]]
+
-
[[Category: Complex]]
+
-
[[Category: Egf-like domain]]
+
-
[[Category: Gamma- carboxyglutamic acid]]
+
-
[[Category: Gamma-carboxyglutamic acid]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydroxylation]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Protease]]
+
-
[[Category: Serine protease]]
+
-
[[Category: Zymogen]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:42:18 2009''
+

Current revision

CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX

PDB ID 2j38

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j38"
Personal tools