2ggp

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{{Seed}}
 
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[[Image:2ggp.png|left|200px]]
 
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==Solution structure of the Atx1-Cu(I)-Ccc2a complex==
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The line below this paragraph, containing "STRUCTURE_2ggp", creates the "Structure Box" on the page.
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<StructureSection load='2ggp' size='340' side='right'caption='[[2ggp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ggp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
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{{STRUCTURE_2ggp| PDB=2ggp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggp OCA], [https://pdbe.org/2ggp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggp RCSB], [https://www.ebi.ac.uk/pdbsum/2ggp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATX1_YEAST ATX1_YEAST] Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners.
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===Solution structure of the Atx1-Cu(I)-Ccc2a complex===
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The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction.,Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato A, Voulgaris P Nat Chem Biol. 2006 Jul;2(7):367-8. Epub 2006 May 28. PMID:16732294<ref>PMID:16732294</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16732294}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ggp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16732294 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_16732294}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2GGP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGP OCA].
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==Reference==
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<ref group="xtra">PMID:16732294</ref><references group="xtra"/>
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[[Category: Copper-exporting ATPase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Banci, L.]]
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[[Category: Banci L]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Cantini, F.]]
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[[Category: Cantini F]]
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[[Category: Felli, I C.]]
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[[Category: Felli IC]]
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[[Category: Gonnelli, L.]]
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[[Category: Gonnelli L]]
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[[Category: Hadjiliadis, N.]]
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[[Category: Hadjiliadis N]]
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[[Category: Pierattelli, R.]]
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[[Category: Pierattelli R]]
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[[Category: Rosato, A.]]
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[[Category: Rosato A]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Voulgaris P]]
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[[Category: Voulgaris, P.]]
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[[Category: Complex]]
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[[Category: Copper transport]]
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[[Category: Nmr]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:45:23 2009''
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Current revision

Solution structure of the Atx1-Cu(I)-Ccc2a complex

PDB ID 2ggp

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