2z1d

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{{Seed}}
 
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[[Image:2z1d.png|left|200px]]
 
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==Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis==
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The line below this paragraph, containing "STRUCTURE_2z1d", creates the "Structure Box" on the page.
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<StructureSection load='2z1d' size='340' side='right'caption='[[2z1d]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z1D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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{{STRUCTURE_2z1d| PDB=2z1d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1d OCA], [https://pdbe.org/2z1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z1d RCSB], [https://www.ebi.ac.uk/pdbsum/2z1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5JII1_THEKO Q5JII1_THEKO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/2z1d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z1d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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[NiFe] hydrogenase maturation proteins HypC, HypD, and HypE catalyze the insertion and cyanation of the iron center of [NiFe] hydrogenases by an unknown mechanism. We have determined the crystal structures of HypC, HypD, and HypE from Thermococcus kodakaraensis KOD1 at 1.8 A, 2.07 A, and 1.55 A resolution, respectively. The structure of HypD reveals its probable iron binding and active sites for cyanation. An extended conformation of each conserved motif of HypC and HypE allows the essential cysteine residues of both proteins to interact with the active site of HypD. Furthermore, the C-terminal tail of HypE is shown to exist in an ATP-dependent dynamic equilibrium between outward and inward conformations. Unexpectedly, the [4Fe-4S] cluster environment of HypD is quite similar to that of ferredoxin:thioredoxin reductase (FTR), indicating the existence of a redox cascade similar to the FTR system. These results suggest a cyanation reaction mechanism via unique thiol redox signaling in the HypCDE complex.
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===Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis===
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Crystal structures of [NiFe] hydrogenase maturation proteins HypC, HypD, and HypE: insights into cyanation reaction by thiol redox signaling.,Watanabe S, Matsumi R, Arai T, Atomi H, Imanaka T, Miki K Mol Cell. 2007 Jul 6;27(1):29-40. PMID:17612488<ref>PMID:17612488</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2z1d" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17612488}}, adds the Publication Abstract to the page
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*[[HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures|HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17612488 is the PubMed ID number.
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*[[HypA-HypB-HypC-HypD-HypE-HypF|HypA-HypB-HypC-HypD-HypE-HypF]]
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== References ==
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{{ABSTRACT_PUBMED_17612488}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2Z1D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermococcus_kodakarensis Thermococcus kodakarensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1D OCA].
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[[Category: Large Structures]]
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[[Category: Thermococcus kodakarensis KOD1]]
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==Reference==
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[[Category: Arai T]]
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<ref group="xtra">PMID:17612488</ref><references group="xtra"/>
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[[Category: Atomi H]]
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[[Category: Thermococcus kodakarensis]]
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[[Category: Imanaka T]]
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[[Category: Arai, T.]]
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[[Category: Matsumi R]]
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[[Category: Atomi, H.]]
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[[Category: Miki K]]
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[[Category: Imanaka, T.]]
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[[Category: Watanabe S]]
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[[Category: Matsumi, R.]]
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[[Category: Miki, K.]]
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[[Category: Watanabe, S.]]
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[[Category: Thiol redox]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:46:14 2009''
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Current revision

Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis

PDB ID 2z1d

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