2qv3

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{{Seed}}
 
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[[Image:2qv3.png|left|200px]]
 
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==Crystal Structure of the Helicobacter pylori Vacuolating Toxin p55 Domain==
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The line below this paragraph, containing "STRUCTURE_2qv3", creates the "Structure Box" on the page.
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<StructureSection load='2qv3' size='340' side='right'caption='[[2qv3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QV3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vacA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qv3 OCA], [https://pdbe.org/2qv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2qv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qv3 ProSAT]</span></td></tr>
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{{STRUCTURE_2qv3| PDB=2qv3 | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/VACA2_HELPX VACA2_HELPX]] Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/2qv3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qv3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. pylori vaccine. Here, we present a 2.4-A crystal structure of the VacA p55 domain, which has an important role in mediating VacA binding to host cells. The structure is predominantly a right-handed parallel beta-helix, a feature that is characteristic of autotransporter passenger domains but unique among known bacterial protein toxins. Notable features of VacA p55 include disruptions in beta-sheet contacts that result in five beta-helix subdomains and a C-terminal domain that contains a disulfide bond. Analysis of VacA protein sequences from unrelated H. pylori strains, including m1 and m2 forms of VacA, allows us to identify structural features of the VacA surface that may be important for interactions with host receptors. Docking of the p55 structure into a 19-A cryo-EM map of a VacA dodecamer allows us to propose a model for how VacA monomers assemble into oligomeric structures capable of membrane channel formation.
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===Crystal Structure of the Helicobacter pylori Vacuolating Toxin p55 Domain===
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Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.,Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16293-8. Epub 2007 Oct 2. PMID:17911250<ref>PMID:17911250</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17911250}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2qv3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17911250 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17911250}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Atcc 43504]]
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2QV3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QV3 OCA].
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[[Category: Large Structures]]
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[[Category: Gangwer, K A]]
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==Reference==
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<ref group="xtra">PMID:17911250</ref><references group="xtra"/>
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[[Category: Helicobacter pylori]]
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[[Category: Gangwer, K A.]]
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[[Category: Beta-helix]]
[[Category: Beta-helix]]
[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Vaca]]
[[Category: Vaca]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:01:23 2009''
 

Current revision

Crystal Structure of the Helicobacter pylori Vacuolating Toxin p55 Domain

PDB ID 2qv3

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