1d0h

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{{Seed}}
 
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[[Image:1d0h.png|left|200px]]
 
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==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE==
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The line below this paragraph, containing "STRUCTURE_1d0h", creates the "Structure Box" on the page.
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<StructureSection load='1d0h' size='340' side='right'caption='[[1d0h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D0H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1d0h| PDB=1d0h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d0h OCA], [https://pdbe.org/1d0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d0h RCSB], [https://www.ebi.ac.uk/pdbsum/1d0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d0h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/1d0h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d0h ConSurf].
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<div style="clear:both"></div>
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===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE===
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==See Also==
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*[[Tetanus toxin|Tetanus toxin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10722735}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10722735 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10722735}}
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==About this Structure==
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1D0H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].
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==Reference==
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<ref group="xtra">PMID:10722735</ref><references group="xtra"/>
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[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
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[[Category: Black, I.]]
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[[Category: Large Structures]]
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[[Category: Charles, I G.]]
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[[Category: Black I]]
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[[Category: Emsley, P.]]
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[[Category: Charles IG]]
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[[Category: Fairweather, N F.]]
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[[Category: Emsley P]]
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[[Category: Fotinou, C.]]
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[[Category: Fairweather NF]]
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[[Category: Hewitt, E.]]
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[[Category: Fotinou C]]
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[[Category: Isaacs, N W.]]
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[[Category: Hewitt E]]
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[[Category: Watts, C.]]
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[[Category: Isaacs NW]]
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[[Category: Beta trefoil]]
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[[Category: Watts C]]
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[[Category: Jelly-roll]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:06:36 2009''
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Current revision

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE

PDB ID 1d0h

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