1z53

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(New page: 200px<br /><applet load="1z53" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z53, resolution 1.13&Aring;" /> '''The 1.13 Angstrom St...)
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[[Image:1z53.gif|left|200px]]<br /><applet load="1z53" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1z53, resolution 1.13&Aring;" />
 
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'''The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase'''<br />
 
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==Overview==
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==The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase==
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The iron-free cytochrome c peroxidase (CCP) crystal structure has been, determined to 1.13 A and compared with the 1.2-A ferric-CCP structure., Quite unexpectedly, removal of the iron has no effect on porphyrin, geometry and distortion, indicating that protein-porphyrin interactions, and not iron coordination or formation of the axial His-Fe bond determines, porphyrin conformation. However, there are changes in solvent structure in, the distal pocket, which lead to changes in the distal His52 acid-base, catalyst. The observed ability of His52 to move in response to small, changes in solvent structure is very likely important for its role as a, catalyst in assisting in the heterolytic fission of the peroxide O-O bond.
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<StructureSection load='1z53' size='340' side='right'caption='[[1z53]], [[Resolution|resolution]] 1.13&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z53 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PP9:PROTOPORPHYRIN+IX'>PP9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z53 OCA], [https://pdbe.org/1z53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z53 RCSB], [https://www.ebi.ac.uk/pdbsum/1z53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z53 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCPR_YEAST CCPR_YEAST] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z53_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z53 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Z53 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with PP9 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z53 OCA].
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*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The 1.13-A structure of iron-free cytochrome c peroxidase., Bhaskar B, Poulos TL, J Biol Inorg Chem. 2005 Jun;10(4):425-30. Epub 2005 May 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15900441 15900441]
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[[Category: Large Structures]]
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[[Category: Cytochrome-c peroxidase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Bhaskar B]]
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[[Category: Bhaskar, B.]]
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[[Category: Poulos TL]]
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[[Category: Poulos, T.L.]]
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[[Category: PP9]]
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[[Category: ccp]]
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[[Category: heme peroxidase]]
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[[Category: iron-free protoporphyrin ix]]
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[[Category: trp cation radical]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:14:32 2007''
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Current revision

The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase

PDB ID 1z53

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