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1lqv
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1lqv.png|left|200px]] | ||
| - | + | ==Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.== | |
| - | + | <StructureSection load='1lqv' size='340' side='right'caption='[[1lqv]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1lqv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqv OCA], [https://pdbe.org/1lqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqv RCSB], [https://www.ebi.ac.uk/pdbsum/1lqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqv ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/EPCR_HUMAN EPCR_HUMAN] Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. | |
| - | + | == Evolutionary Conservation == | |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqv_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | == | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqv ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dauter | + | [[Category: Large Structures]] |
| - | [[Category: Dongfeng | + | [[Category: Dauter Z]] |
| - | [[Category: Esmon | + | [[Category: Dongfeng Q]] |
| - | [[Category: Esmon | + | [[Category: Esmon CT]] |
| - | [[Category: Oganesyan | + | [[Category: Esmon NL]] |
| - | [[Category: Oganesyan | + | [[Category: Oganesyan N]] |
| - | [[Category: Terzyan | + | [[Category: Oganesyan V]] |
| - | + | [[Category: Terzyan S]] | |
| - | + | ||
| - | + | ||
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Current revision
Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.
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Categories: Homo sapiens | Large Structures | Dauter Z | Dongfeng Q | Esmon CT | Esmon NL | Oganesyan N | Oganesyan V | Terzyan S

