1zr9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:12, 15 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1zr9.png|left|200px]]
 
-
<!--
+
==Solution Structure of a Human C2H2-type Zinc Finger Protein==
-
The line below this paragraph, containing "STRUCTURE_1zr9", creates the "Structure Box" on the page.
+
<StructureSection load='1zr9' size='340' side='right'caption='[[1zr9]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1zr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZR9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1zr9| PDB=1zr9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr9 OCA], [https://pdbe.org/1zr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zr9 ProSAT], [https://www.topsan.org/Proteins/CESG/1zr9 TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ZN593_HUMAN ZN593_HUMAN] Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zr9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zr9 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Here, we report the solution structure of ZNF593, a protein identified in a functional study as a negative modulator of the DNA-binding activity of the Oct-2 transcription factor. ZNF593 contains a classic C(2)H(2) zinc finger domain flanked by about 40 disordered residues on each terminus. Although the protein contains a high degree of intrinsic disorder, the structure of the zinc finger domain was resolved by NMR spectroscopy without a need for N- or C-terminal truncations. The tertiary structure of the zinc finger domain is composed of a beta-hairpin that positions the cysteine side chains for zinc coordination, followed by an atypical kinked alpha-helix containing the two histidine side chain ligands. The structural topology of ZNF593 is similar to a fragment of the double-stranded RNA-binding protein Zfa and the C-terminal zinc finger of MBP-1, a human enhancer binding protein. The structure presented here will provide a guide for future functional studies of how ZNF593 negatively modulates the DNA-binding activity of Oct-2, a POU domain-containing transcription factor. Our work illustrates the unique capacity of NMR spectroscopy for structural analysis of folded domains in a predominantly disordered protein.
-
===Solution Structure of a Human C2H2-type Zinc Finger Protein===
+
The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.,Hayes PL, Lytle BL, Volkman BF, Peterson FC Protein Sci. 2008 Mar;17(3):571-6. PMID:18287285<ref>PMID:18287285</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18287285}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1zr9" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18287285 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18287285}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1ZR9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR9 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18287285</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+
[[Category: Large Structures]]
-
[[Category: Lytle, B L.]]
+
[[Category: Lytle BL]]
-
[[Category: Peterson, F C.]]
+
[[Category: Peterson FC]]
-
[[Category: Volkman, B F.]]
+
[[Category: Volkman BF]]
-
[[Category: Center for eukaryotic structural genomic]]
+
-
[[Category: Cesg]]
+
-
[[Category: Dna binding]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transcription]]
+
-
[[Category: Zinc finger]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:54:29 2009''
+

Current revision

Solution Structure of a Human C2H2-type Zinc Finger Protein

PDB ID 1zr9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zr9"
Personal tools