2gfc

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{{Seed}}
 
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[[Image:2gfc.png|left|200px]]
 
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==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==
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The line below this paragraph, containing "STRUCTURE_2gfc", creates the "Structure Box" on the page.
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<StructureSection load='2gfc' size='340' side='right'caption='[[2gfc]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GFC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_2gfc| PDB=2gfc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gfc OCA], [https://pdbe.org/2gfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gfc RCSB], [https://www.ebi.ac.uk/pdbsum/2gfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gfc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IPKA_RABIT IPKA_RABIT] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gfc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gfc ConSurf].
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<div style="clear:both"></div>
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===cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24===
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==See Also==
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16699172}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16699172 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16699172}}
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==About this Structure==
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2GFC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFC OCA].
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==Reference==
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<ref group="xtra">PMID:16699172</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Bonn, S.]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Bossemeyer, D.]]
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[[Category: Bonn S]]
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[[Category: Breitenlechner, C B.]]
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[[Category: Bossemeyer D]]
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[[Category: Engh, R A.]]
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[[Category: Breitenlechner CB]]
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[[Category: Gassel, M.]]
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[[Category: Engh RA]]
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[[Category: Herrero, S.]]
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[[Category: Gassel M]]
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[[Category: Binary complex]]
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[[Category: Herrero S]]
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[[Category: Peptide inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:55:27 2009''
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Current revision

cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24

PDB ID 2gfc

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